EP 0664706 A1 19950802 - PROTEIN KINASE C INHIBITION AND NOVEL COMPOUND BALANOL.
Title (en)
PROTEIN KINASE C INHIBITION AND NOVEL COMPOUND BALANOL.
Title (de)
HEMMUNG DER PROTEIN KINASE C UND NEUE VERBINDUNG BALANOL.
Title (fr)
INHIBITION DE PROTEINE-KINASE C ET NOUVEAU COMPOSE APPELE BALANOL.
Publication
Application
Priority
- US 9207124 W 19920821
- US 74863291 A 19910822
Abstract (en)
[origin: WO9303730A1] Balanol, which is derived from fungi of the genus Verticillium, especially the fungus Verticillium balanoides, is provided. Balanol, when substantially pure, is soluble in dimethyl sulfoxide, water, and methanol; insoluble in ethyl acetate and chloroform; gives a positive color reaction with polymolybdic acid, ninhydrin reagent, and ferric chloride; is negative with Dragendorff's reagent and Iodoplatinate spray; has an Rf value of approximately 0.58 with silica gel thin layer chromatography with n-butanol/acetic acid/water at a ratio of 4:1:1 respectively; and has a molecular weight of approximately 550. Compounds of the invention are useful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.
IPC 1-7
IPC 8 full level
A61K 31/55 (2006.01); A61K 31/625 (2006.01); A61K 35/74 (2006.01); A61P 9/00 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 223/12 (2006.01); C12N 9/99 (2006.01); C12P 17/10 (2006.01); C12R 1/645 (2006.01)
CPC (source: EP)
A61P 9/00 (2017.12); A61P 29/00 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07D 223/12 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE
DOCDB simple family (publication)
WO 9303730 A1 19930304; AU 2504192 A 19930316; CA 2115994 A1 19930304; EP 0664706 A1 19950802; EP 0664706 A4 19950614; JP H06510280 A 19941117
DOCDB simple family (application)
US 9207124 W 19920821; AU 2504192 A 19920821; CA 2115994 A 19920821; EP 92919060 A 19920821; JP 50244693 A 19920821