Global Patent Index - EP 0664706 A4

EP 0664706 A4 19950614 - PROTEIN KINASE C INHIBITION AND NOVEL COMPOUND BALANOL.

Title (en)

PROTEIN KINASE C INHIBITION AND NOVEL COMPOUND BALANOL.

Title (de)

HEMMUNG DER PROTEIN KINASE C UND NEUE VERBINDUNG BALANOL.

Title (fr)

INHIBITION DE PROTEINE-KINASE C ET NOUVEAU COMPOSE APPELE BALANOL.

Publication

EP 0664706 A4 19950614 (EN)

Application

EP 92919060 A 19920821

Priority

  • US 9207124 W 19920821
  • US 74863291 A 19910822

Abstract (en)

[origin: WO9303730A1] Balanol, which is derived from fungi of the genus Verticillium, especially the fungus Verticillium balanoides, is provided. Balanol, when substantially pure, is soluble in dimethyl sulfoxide, water, and methanol; insoluble in ethyl acetate and chloroform; gives a positive color reaction with polymolybdic acid, ninhydrin reagent, and ferric chloride; is negative with Dragendorff's reagent and Iodoplatinate spray; has an Rf value of approximately 0.58 with silica gel thin layer chromatography with n-butanol/acetic acid/water at a ratio of 4:1:1 respectively; and has a molecular weight of approximately 550. Compounds of the invention are useful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.

IPC 1-7

A61K 31/55; C07D 223/02; C07D 223/08; C07D 223/12

IPC 8 full level

A61K 31/55 (2006.01); A61K 31/625 (2006.01); A61K 35/74 (2006.01); A61P 9/00 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 223/12 (2006.01); C12N 9/99 (2006.01); C12P 17/10 (2006.01); C12R 1/645 (2006.01)

CPC (source: EP)

A61P 9/00 (2017.12); A61P 29/00 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07D 223/12 (2013.01)

Citation (search report)

  • [X] W.A.KÖNIG ET AL.: "Konstitution von Oghiocordin, einem Antibioticum mit antifungischen Eigenschaften", CHEM.BER., vol. 113, no. 6, pages 2221 - 26
  • [T] C.BOROS ET AL.: "Comparision of Balanol from Verticillium balanoides and Ophiocordin from Cordyceps ophioglossoides", J.ANTIBIOT., vol. 47, no. 9, pages 1010 - 16
  • See references of WO 9303730A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE

DOCDB simple family (publication)

WO 9303730 A1 19930304; AU 2504192 A 19930316; CA 2115994 A1 19930304; EP 0664706 A1 19950802; EP 0664706 A4 19950614; JP H06510280 A 19941117

DOCDB simple family (application)

US 9207124 W 19920821; AU 2504192 A 19920821; CA 2115994 A 19920821; EP 92919060 A 19920821; JP 50244693 A 19920821