EP 0664803 A1 19950802 - N-ARYLHETEROARYLALKYL 1-CYCLOALKYL-IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS.
Title (en)
N-ARYLHETEROARYLALKYL 1-CYCLOALKYL-IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS.
Title (de)
N.ARYLHETEROARYLALKYL 1-CYCLOALKYLIMIDAZOL-2-ON VERBINDUNGEN BEI DER BEHANDLUNG VON ZIRKULATORISCHEN STÖRUNGEN.
Title (fr)
COMPOSES N-ARYLHETEROARYLALKYLE 1-CYCLOALKYLE-IMIDAZOLE-2-ONE POUR LE TRAITEMENT DES MALADIES CIRCULATOIRES.
Publication
Application
Priority
- US 9305601 W 19930616
- US 95957592 A 19921013
Abstract (en)
[origin: WO9408989A1] A class of N-arylheteroarylalkyl 1-cycloalkyl-imidazol-2-one compounds is described for use in treatment of circulatory disorders such as hypertension and congestive heart failure. Compounds of particular interest are angiotension II antagonists of formula (A), wherein A is selected from (a), (b), (c), (d), (e) and (f); wherein each of R<1>, R<2> and R<3> is independently selected from hydrido, alkyl, alkoxy, halo, hydroxy, carboxyl, alkoxycarbonyl, formyl and acetyl; wherein R<7> is hydrido; R<8> is alkyl; wherein R<9> is an acidic group selected from COOH and (g); or a stereoisomer or a tautomer thereof or a pharmaceutically-acceptable salt thereof.
IPC 1-7
IPC 8 full level
C07D 401/06 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61P 9/00 (2006.01); A61P 9/12 (2006.01); C07D 401/10 (2006.01); C07D 401/14 (2006.01)
CPC (source: EP)
A61P 9/00 (2017.12); A61P 9/12 (2017.12); C07D 401/14 (2013.01)
Citation (search report)
See references of WO 9408989A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL SE
DOCDB simple family (publication)
WO 9408989 A1 19940428; AU 4533693 A 19940509; CA 2143192 A1 19940428; EP 0664803 A1 19950802; JP H08502285 A 19960312
DOCDB simple family (application)
US 9305601 W 19930616; AU 4533693 A 19930616; CA 2143192 A 19930616; EP 93915307 A 19930616; JP 50996194 A 19930616