EP 0664813 A4 19980527 - CETP INHIBITOR POLYPEPTIDE, ANTIBODIES AGAINST THE SYNTHETIC POLYPEPTIDE AND PROPHYLACTIC AND THERAPEUTIC ANTI-ATHEROSCLEROSIS TREATMENTS.
Title (en)
CETP INHIBITOR POLYPEPTIDE, ANTIBODIES AGAINST THE SYNTHETIC POLYPEPTIDE AND PROPHYLACTIC AND THERAPEUTIC ANTI-ATHEROSCLEROSIS TREATMENTS.
Title (de)
CETP INHIBITORPOLYPEPTID, ANTIKÖRPER GEGEN DAS SYNTHETISCHE POLYPEPTID UND PHROPHYLAKTISCHE UND THERAPEUTISCHE ANTI-ARTERIOSKLEOSE BEHANDLUNG.
Title (fr)
POLYPEPTIDE INHIBITEUR DE CETP, ANTICORPS CONTRE CE POLYPEPTIDE SYNTHETIQUE ET TRAITEMENTS PROPHYLACTIQUE ET THERAPEUTIQUE DE L'ATHEROSCLEROSE.
Publication
Application
Priority
- US 10216093 A 19930804
- US 9408624 W 19940802
Abstract (en)
[origin: WO9504755A1] A polypeptide and analogues thereof inhibit cholesteryl ester transfer protein (CETP). An anti-atherosclerosis composition comprises an anti-atherosclerosis effective amount of the polypeptide and a pharmaceutically acceptable carrier. An anti-atherosclerosis kit comprises in separate sterile containers at least one unit of the composition containing the polypeptide, one syringe and one needle. An antibody has specificity for the polypeptide of the invention, the baboon CETP 4kD polypeptide inhibitor, the 1-36 amino acid N-terminal fragment of apo C-I, modified apo A-I (MW:31kD) or modified apo E (MW:41kD). A method of preventing atherosclerosis in a mammal being predisposed to that condition comprises administering to the mammal a prophylactically effective amount of the polypeptide of the invention, and a method of treating a mammal afflicted with atherosclerosis comprises the administration of a therapeutically effective amount of the polypeptide disclosed herein.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61P 9/10 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01)
CPC (source: EP KR)
A61K 38/17 (2013.01 - KR); A61P 9/10 (2017.12 - EP); C07K 14/435 (2013.01 - KR); C07K 14/4703 (2013.01 - EP); C07K 16/18 (2013.01 - EP KR); A61K 38/00 (2013.01 - EP)
Citation (search report)
- [X] WO 9311782 A1 19930624 - SOUTHWEST FOUND BIOMED RES [US]
- See references of WO 9504755A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9504755 A1 19950216; AU 683295 B2 19971106; AU 7552694 A 19950228; CA 2145767 A1 19950216; EP 0664813 A1 19950802; EP 0664813 A4 19980527; JP H08502525 A 19960319; KR 950703580 A 19950920
DOCDB simple family (application)
US 9408624 W 19940802; AU 7552694 A 19940802; CA 2145767 A 19940802; EP 94925711 A 19940802; JP 50646495 A 19940802; KR 19950701273 A 19950403