EP 0666867 A4 19970827 - REAGENTS AND METHODS FOR TREATING RHEUMATOID ARTHRITIS.
Title (en)
REAGENTS AND METHODS FOR TREATING RHEUMATOID ARTHRITIS.
Title (de)
REAGENTIEN UND METHODEN ZUR BEHANDLUNG RHEUMATOISCHER ARTHRITIS.
Title (fr)
REACTIFS ET PROCEDES DE TRAITEMENT DE L'ARTHRITE RHUMATOIDE.
Publication
Application
Priority
- US 9308644 W 19930914
- US 94341892 A 19920914
Abstract (en)
[origin: WO9406823A1] The present invention is directed to agents for and methods of treating rheumatoid arthritis. Antibodies against MHC HLA DQw2 are administered to DQw2 patients with rheumatoid arthritis. Alternatively, peptides are developed that mimic the self peptides presented to the T-lymphocytes of these patients. These peptides prevent T cell activation stimulated by self peptides derived from DQw2 itself, V(alpha) 12.1, an allele whose expression is found on expanded T cell clones of these patients, and other autologous antigens.
IPC 1-7
C07K 5/04; C07K 7/04; C07K 15/28; A61K 38/00; A61K 38/16; A61K 39/395
IPC 8 full level
A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61P 29/00 (2006.01); C07K 7/08 (2006.01); C07K 14/74 (2006.01); C07K 16/28 (2006.01)
CPC (source: EP)
A61P 29/00 (2017.12); C07K 14/70539 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
- [X] WO 9212996 A2 19920806 - IMMUNE RESPONSE CORP INC [US]
- [PA] DERSIMONIAN H. ET AL.: "Clonal V-alpha-12.1+ T-cell expansions in the peripheral blood of rheumatiod arthritis patients", J. EXP. MED., vol. 177, no. 6, June 1993 (1993-06-01), pages 1623 - 1631, XP000653034
- See references of WO 9406823A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9406823 A1 19940331; AU 4920093 A 19940412; CA 2144044 A1 19940331; EP 0666867 A1 19950816; EP 0666867 A4 19970827; JP H08501554 A 19960220
DOCDB simple family (application)
US 9308644 W 19930914; AU 4920093 A 19930914; CA 2144044 A 19930914; EP 93921548 A 19930914; JP 50823994 A 19930914