EP 0668907 A1 19950830 - GLYCOPROTEIN LIGAND FOR P-SELECTIN AND METHODS OF USE THEREOF.
Title (en)
GLYCOPROTEIN LIGAND FOR P-SELECTIN AND METHODS OF USE THEREOF.
Title (de)
GLYCOPROTEINLIGAND FÜR P-SELECTION UND VERFAHREN ZUR DESSEN VERWENDUNG.
Title (fr)
LIGAND CLYCOPROTEIQUE POUR LA P-SELECTINE ET SON PROCEDE D'UTILISATION.
Publication
Application
Priority
- US 9311129 W 19931116
- US 97655292 A 19921116
Abstract (en)
[origin: WO9411498A1] P-selectin has been demonstrated to bind primarily to a single glycoprotein ligand on neutrophils and HL-60 cells, when assessed by blotting assays and by affinity chromatography of [<3>H]glucosamine-labeled HL-60 cell extracts on immobilized P-selectin. This molecule was characterized and distinguished from other well-characterized neutrophil membrane proteins with similar apparent molecular mass. The purified ligand, or fragments thereof, including both the carbohydrate and protein components, or antibodies to the ligand, or fragments or components thereof, can be used as inhibitors of binding of P-selectin to cells.
IPC 1-7
IPC 8 full level
C07K 14/705 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/70596 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9411498A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9411498 A1 19940526; AU 5727594 A 19940608; AU 681369 B2 19970828; CA 2151142 A1 19940526; CA 2151142 C 20011002; EP 0668907 A1 19950830
DOCDB simple family (application)
US 9311129 W 19931116; AU 5727594 A 19931116; CA 2151142 A 19931116; EP 94903270 A 19931116