EP 0669939 A1 19950906 - SOMATOTROPIN MODIFICATIONS.
Title (en)
SOMATOTROPIN MODIFICATIONS.
Title (de)
Modifizierung von Somatotropin.
Title (fr)
MODIFICATIONS DE LA SOMATOTROPHINE.
Publication
Application
Priority
- US 9309232 W 19931004
- US 97109892 A 19921028
Abstract (en)
[origin: WO9410200A1] Somatotropin modifications are described that have unexpected enhancements in conformational and chemical stability without loss of bioactivity. Alterations of these characteristics are obtained via modification of somatotropins by site-directed mutagenesis. These changes increase the storage stability of these proteins. Exemplary modifications include porcine somatotropins having histidine and arginine substitutions for glutamine and histidine at positions 19 and 20, respectively (Q19H, H20R), having glutamic acid substituted for phenylalanine at position 52 (F52E), and having glutamic acid substituted for leucine at position 137 (I137E). The modified somatotropins are useful to enhance growth characteristics in animal species, e.g., to increase the lean-to-fat ratio in pigs and milk production in cows.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 38/27 (2006.01); A61P 15/00 (2006.01); A61P 15/14 (2006.01); C07K 7/08 (2006.01); C07K 14/61 (2006.01); C12N 15/18 (2006.01); C12P 21/02 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 15/00 (2017.12); A61P 15/14 (2017.12); C07K 14/61 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9410200A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9410200 A1 19940511; AU 5142293 A 19940524; CA 2145546 A1 19940511; EP 0669939 A1 19950906; JP H08502963 A 19960402; MX 9306676 A 19940429; ZA 936811 B 19950315
DOCDB simple family (application)
US 9309232 W 19931004; AU 5142293 A 19931004; CA 2145546 A 19931004; EP 93922424 A 19931004; JP 51106194 A 19931004; MX 9306676 A 19931027; ZA 936811 A 19930915