Global Patent Index - EP 0670734 A4

EP 0670734 A4 19980114 - A SUBPOPULATION OF MAC-1 (CD11B/CD18) MOLECULES WHICH MEDIATE NEUTROPHIL ADHESION TO ICAM-1 AND FIBRINOGEN.

Title (en)

A SUBPOPULATION OF MAC-1 (CD11B/CD18) MOLECULES WHICH MEDIATE NEUTROPHIL ADHESION TO ICAM-1 AND FIBRINOGEN.

Title (de)

EINE SUBPOPULATION VON MAC-1 (CD11B/CD 18) MOLEKÜLEN WELCHE EINE NEUTROPHILE ADHÄSION AN ICAM-1 UND FIBRINOGEN VERMITTELN.

Title (fr)

SOUS-POPULATION DE MOLECULES Mac-1 (CD11B/CD 18) QUI INDUISENT L'ADHESION NEUTROPHILE A ICAM-1 ET AU FIBRINOGENE.

Publication

EP 0670734 A4 19980114 (EN)

Application

EP 93924919 A 19931012

Priority

  • US 9309777 W 19931012
  • US 95890492 A 19921009
  • US 96415692 A 19921022

Abstract (en)

[origin: WO9408620A1] The present invention is based on the novel observation that upon stimulation of resting myeloid cells, not all of the Mac-1 molecules expressed by the cell become activate. Only select subpopulations of Mac-1 molecules are activated and become capable of binding ligand. Further, the activated Mac-1 molecules were found to possess activation specific epitopes which distinguishes them from non-activated Mac-1 molecules. Based on these observations antibodies are described which selectively bind activated Mac-1 molecules but are substantially incapable of binding non-activated Mac-1.

IPC 1-7

A61K 39/395; C07K 15/28

IPC 8 full level

A61K 39/395 (2006.01); A61P 29/00 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

A61P 29/00 (2017.12); C07K 14/70553 (2013.01); C07K 16/2845 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [Y] EP 0364690 A2 19900425 - DANA FARBER CANCER INST INC [US]
  • [Y] WO 8809672 A1 19881215 - UNIV MICHIGAN [US], et al
  • [Y] WO 8900190 A1 19890112 - DANA FARBER CANCER INST INC [US]
  • [AD] EP 0488061 A2 19920603 - BLOOD RES LAB CENTER [US]
  • [XY] ELEMER G ET AL: "Monoclonal antibody 7A10 defines a functional neoepitope of the leukocyte integrin CD11B-CD18 MAC - 1", 1992 MEETING OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB), PART II, ANAHEIM, CALIFORNIA, USA, APRIL 5-9, 1992. FASE (FED AM SOC EXP BIOL) J. (1992) 6 (5), A1893. CODEN: FAJOEC. ISSN: 0892-6638., XP002094274
  • [XY] SPRINGER T ET AL: "Mac - 1: a macrophage differentiation antigen identified by monoclonal antibody.", EUROPEAN JOURNAL OF IMMUNOLOGY, (1979 APR) 9 (4) 301-6. JOURNAL CODE: EN5. ISSN: 0014-2980., GERMANY, WEST: Germany, Federal Republic of, XP002094275
  • [XY] BROWN E J ET AL: "Mechanism of inhibition of immunoglobulin G-mediated phagocytosis by monoclonal antibodies that recognize the Mac - 1 antigen.", JOURNAL OF CLINICAL INVESTIGATION, (1988 FEB) 81 (2) 365-75. JOURNAL CODE: HS7. ISSN: 0021-9738., United States, XP002094276
  • [XY] DANA N ET AL: "Two functional domains in the phagocyte membrane glycoprotein MO1 identified with monoclonal antibodies", JOURNAL OF IMMUNOLOGY, vol. 137, no. 10, 15 November 1986 (1986-11-15), pages 3259 - 3263, XP000655020
  • [Y] COLLET B ET AL: "Scintigraphic detection in mice of inflammatory lesions and tumours by an indium-labelled monoclonal antibody directed against Mac - 1 antigen.", CANCER IMMUNOLOGY, IMMUNOTHERAPY, (1988) 26 (3) 237-42. JOURNAL CODE: CN3. ISSN: 0340-7004., GERMANY, WEST: Germany, Federal Republic of, XP002094277
  • [Y] DING A ET AL: "Activation of mouse peritoneal macrophages by monoclonal antibodies to Mac - 1 (complement receptor type 3).", JOURNAL OF EXPERIMENTAL MEDICINE, (1987 MAR 1) 165 (3) 733-49. JOURNAL CODE: I2V. ISSN: 0022-1007., United States, XP002094278
  • [Y] SCHEINBERG D A: "Current applications of monoclonal antibodies for the therapy of hematopoietic cancers.", CURRENT OPINION IN IMMUNOLOGY, (1991 OCT) 3 (5) 679-84. REF: 47 JOURNAL CODE: AH1. ISSN: 0952-7915., ENGLAND: United Kingdom, XP002094279
  • [DA] KISHIMOTO ET AL.: "The leukocyte integrins", ADVANCES IN IMMUNOLOGY, vol. 46, 1989, pages 149 - 182, XP000655002
  • [PX] DIAMOND M S ET AL: "A Subpopulation of MAC-1 (CD11B/CD18) Molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen", JOURNAL OF CELL BIOLOGY, vol. 120, no. 2, January 1993 (1993-01-01), pages 545 - 556, XP000655147
  • [T] LUK, JOHN ET AL: "Subunit specificity and epitope mapping of Mac-1 and p150,95 mAb using chimeric CD11b X CD11c transfectants", LEUCOCYTE TYPING V: WHITE CELL DIFFER. ANTIGENS, PROC. INT. WORKSHOP CONF., 5TH (1995), MEETING DATE 1993, VOLUME 2, 1599-1601. EDITOR(S): SCHLOSSMAN, STUART F. PUBLISHER: OXFORD UNIVERSITY PRESS, OXFORD, UK. CODEN: 63WDAC, XP002094280
  • [T] DIAMOND M S ET AL: "The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b /CD18) for four distinct adhesion ligands.", JOURNAL OF CELL BIOLOGY, (1993 FEB) 120 (4) 1031-43. JOURNAL CODE: HMV. ISSN: 0021-9525., United States, XP002094281
  • See references of WO 9408620A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9408620 A1 19940428; AU 5442394 A 19940509; AU 674556 B2 19970102; CA 2144738 A1 19940428; EP 0670734 A1 19950913; EP 0670734 A4 19980114; JP H08502956 A 19960402

DOCDB simple family (application)

US 9309777 W 19931012; AU 5442394 A 19931012; CA 2144738 A 19931012; EP 93924919 A 19931012; JP 51023494 A 19931012