Global Patent Index - EP 0672054 A4

EP 0672054 A4 19960207 - A NOVEL MOLECULE WHICH INHIBITS NEUROPEPTIDE TYROSINE BIOLOGICAL FUNCTION.

Title (en)

A NOVEL MOLECULE WHICH INHIBITS NEUROPEPTIDE TYROSINE BIOLOGICAL FUNCTION.

Title (de)

EIN DIE BIOLOGISCHE FUNKTION DES NEUROPEPTIDS TYROSIN INHIBIERENDES NEUARTIGES MOLEKÜL.

Title (fr)

NOUVELLE MOLECULE INHIBANT LA FONCTION BIOLOGIQUE DU NEUROPEPTIDE TYROSINE.

Publication

EP 0672054 A4 19960207 (EN)

Application

EP 93901575 A 19921221

Priority

  • AU 9200673 W 19921221
  • AU PL010691 A 19911219

Abstract (en)

[origin: WO9312139A1] The present invention provides a novel molecule which inhibits the biological activity of neuropeptide tyrosine (NPY). The molecule of the present invention binds with an affinity of at least 100 nM to one of the helical domains of NPY in a manner such that NPY with the molecule bound thereto cannot bind to the NPY-Y1 receptor. It is preferred that the molecule of the present invention is a peptide and preferably a peptide of the sequence Ser-Ala-Leu-Arg-His-Tyr-NH2. The present invention also relates to compositions including this molecule and to the use of these compositions in treating a range of disease states.

IPC 1-7

C07K 7/06; C07K 7/08; C07K 14/00; A61K 38/00

IPC 8 full level

A61K 38/00 (2006.01); A61P 3/04 (2006.01); A61P 3/08 (2006.01); A61P 3/10 (2006.01); A61P 9/00 (2006.01); A61P 9/12 (2006.01); A61P 25/02 (2006.01); A61P 25/28 (2006.01); C07K 5/12 (2006.01); C07K 7/06 (2006.01); C07K 14/575 (2006.01)

CPC (source: EP)

A61P 3/04 (2017.12); A61P 3/08 (2017.12); A61P 3/10 (2017.12); A61P 9/00 (2017.12); A61P 9/12 (2017.12); A61P 25/02 (2017.12); A61P 25/28 (2017.12); C07K 14/57545 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [X] EP 0225020 A2 19870610 - BEECHAM GROUP PLC [GB]
  • [X] CH 490338 A 19700515 - CIBA GEIGY [CH]
  • [A] WO 9108223 A1 19910613 - BASF AG [DE]
  • [E] WO 9309227 A1 19930513 - GARVAN INST MED RES [AU]
  • [X] BALASUBRAMANIAN, A. ET AL.: "Synthseis and receptor affinities of partial sequences of peptide YY (PYY)", PEPTIDE RESEARCH, vol. 1, no. 1, pages 32 - 35, XP002039197
  • [X] SERVIN, A.L. ET AL.: "Peptide-YY and Neuropeptide-Y inhibit vasoactive intestinal peptide-stimulated ...", ENDOCRINOLOGY, vol. 124, no. 2, pages 692 - 700
  • [X] LACOMBE, J.M. ET AL.: "Malaria invasion of human erythrocytes", INT. J. PEPTIDE PROTEIN RES., vol. 32, pages 104 - 116, XP009038013
  • See references of WO 9312139A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9312139 A1 19930624; CA 2126212 A1 19930708; EP 0672054 A1 19950920; EP 0672054 A4 19960207; JP H08501055 A 19960206

DOCDB simple family (application)

AU 9200673 W 19921221; CA 2126212 A 19921221; EP 93901575 A 19921221; JP 51046793 A 19921221