EP 0673259 A1 19950927 - A METHOD FOR TRANSPLANTING CELLS INTO THE BRAIN AND THERAPEUTIC USES THEREFOR.
Title (en)
A METHOD FOR TRANSPLANTING CELLS INTO THE BRAIN AND THERAPEUTIC USES THEREFOR.
Title (de)
METHODE ZUR TRANSPLANTATION VON ZELLEN INS GEHIRN UND THERAPEUTISCHE VERWENDUNGEN DAVON.
Title (fr)
PROCEDE DE TRANSPLANTATION DE CELLULES DANS LE CERVEAU ET UTILISATIONS THERAPEUTIQUES DE CE PROCEDE.
Publication
Application
Priority
- US 9300494 W 19930121
- US 82365492 A 19920123
Abstract (en)
[origin: WO9314790A1] A method for grafting a cell in the brain of a mammalian subject is accomplished by attaching the cell to a support matrix so that the cell attaches to the matrix surface, and implanting the support matrix with the attached cell into the brain. Preferred support matrices are glass or plastic microbeads, either solid or porous, having a diameter from about 90 to about 125 mu m. The method employs cells of different types, preferably cells of neural or paraneural origin, such as adrenal chromaffin cells. Also useful are cell lines grown in vitro. Cells not of neural or paraneural origin, such as fibroblasts, may also be used following genetic alteration to express a desired neural product such as a neurotransmitter or a neuronal growth factor. The method is used to treat neurological diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, epilepsy, and traumatic brain injury.
IPC 1-7
A61K 48/00; A61K 35/30; A61K 35/12; A61K 9/16; C12N 5/10; C12N 11/02; C12N 11/08; C12N 11/10; C12N 11/12; C12N 11/14
IPC 8 full level
A61K 9/00 (2006.01); A61K 9/16 (2006.01); A61K 35/12 (2006.01); A61K 35/22 (2015.01); A61K 35/30 (2015.01); A61K 35/33 (2015.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); A61L 27/38 (2006.01); A61P 25/00 (2006.01); C12N 5/071 (2010.01)
CPC (source: EP)
A61K 9/0085 (2013.01); A61K 9/1676 (2013.01); A61K 35/22 (2013.01); A61K 35/30 (2013.01); A61K 35/33 (2013.01); A61K 47/6923 (2017.07); A61K 47/6927 (2017.07); A61K 48/00 (2013.01); A61L 27/3813 (2013.01); A61L 27/3878 (2013.01); A61P 25/00 (2017.12); C12N 5/0614 (2013.01); C12N 5/0621 (2013.01); C12N 2502/08 (2013.01); C12N 2531/00 (2013.01); C12N 2533/12 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9314790 A1 19930805; AU 3586993 A 19930901; CA 2128630 A1 19930805; EP 0673259 A1 19950927; EP 0673259 A4 19951206; JP H07503467 A 19950413
DOCDB simple family (application)
US 9300494 W 19930121; AU 3586993 A 19930121; CA 2128630 A 19930121; EP 93904541 A 19930121; JP 51330593 A 19930121