EP 0675873 A4 20000329 - SYNTHESIS OF ENCODED POLYMERS
Title (en)
SYNTHESIS OF ENCODED POLYMERS
Title (de)
HERSTELLUNG VON KODIERTEN POLYMEREN
Title (fr)
SYNTHESE DE POLYMERES CODES
Publication
Application
Priority
- US 9312013 W 19931210
- US 98827892 A 19921211
Abstract (en)
[origin: WO9413623A1] Conjugates and methods of producing the conjugates and mixtures thereof are disclosed. Conjugates are comprised of an active polymer made up of monomer units selected from the group consisting of the monomer units of peptides and/or peptoids, and an encoding polymer comprised of encoding monomers wherein the encoding polymer corresponds to the active polymer, and a coupling moiety covalently coupled to the active polymer and the encoding polymer. In accordance with the synthesis methodology, mixtures of large numbers of conjugates are produced by providing a coupling moiety and covalent binding it to an active monomer and an encoding monomer. Additional monomer units are added to the active monomer to create an active polymer and additional monomer units are added to the encoding monomer to produce an encoding polymer until the desired length is reached for the active polymer. Mixtures of conjugates attached to support bases can be used to assay a sample. The sample is brought into contact with the conjugates and a determination is made with respect to which active proteins bind to receptor sites within the sample. When active binding proteins are determined, the encoding polymer associated with the active polymer is sequenced, and by deduction, the sequence of the active polymer is determined.
IPC 1-7
C07C 237/00; C07H 21/00; C07K 1/00; C07K 5/00; C07K 7/00; C07K 13/00; C07K 17/00
IPC 8 full level
C07C 237/22 (2006.01); C07H 21/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C07K 1/04 (2006.01); C40B 70/00 (2006.01)
CPC (source: EP)
C07H 21/00 (2013.01); C07K 1/04 (2013.01); B01J 2219/00572 (2013.01); C40B 70/00 (2013.01)
Citation (search report)
- [PX] WO 9306121 A1 19930401 - AFFYMAX TECH NV [NL]
- [E] WO 9408051 A1 19940414 - UNIV COLUMBIA [US], et al
- [A] R.J. SIMON ET AL.: "Peptoids: A modular approach to drug discovery", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 89, October 1992 (1992-10-01), WASHINGTON US, pages 9367 - 9371, XP002128602
- [PX] J.M. KERR ET AL.: "Encoded Combinatorial Peptide Libraries Containing Non-Natural Amino Acids", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 115, 24 March 1993 (1993-03-24), DC US, pages 2529 - 2531, XP002128603
- [PX] J. NIELSEN ET AL.: "Synthetic Methods for the Implementation of Encoded Combinatorial Chemistry", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 115, 3 November 1993 (1993-11-03), DC US, pages 9812 - 9813, XP002128604
- See references of WO 9413623A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9413623 A1 19940623; AU 5827294 A 19940704; CA 2151473 A1 19940623; EP 0675873 A1 19951011; EP 0675873 A4 20000329; JP H08504444 A 19960514
DOCDB simple family (application)
US 9312013 W 19931210; AU 5827294 A 19931210; CA 2151473 A 19931210; EP 94904077 A 19931210; JP 51442593 A 19931210