EP 0676960 A1 19951018 - CYCLOALKYL AMINE BIS-ARYL SQUALENE SYNTHASE INHIBITORS.
Title (en)
CYCLOALKYL AMINE BIS-ARYL SQUALENE SYNTHASE INHIBITORS.
Title (de)
SQUALEN-SYNTHASE-INHIBITOREN MIT CYCLOALKYLAMIN-BIS-ARYL-STRUKTUR.
Title (fr)
INHIBITEURS DE SQUALENE SYNTHASE CYCLOALKYLAMINE BIS-ARYLE.
Publication
Application
Priority
- US 9312638 W 19931229
- US 99781892 A 19921229
Abstract (en)
[origin: WO9414435A1] This invention relates to a class of novel polycyclic compounds containing a cycloalkyl ring having substituted thereon a primary amine and which is further linked or bridged to two mono- and/or bicyclic rings and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
IPC 1-7
IPC 8 full level
C07D 317/58 (2006.01); A61K 31/135 (2006.01); A61K 31/335 (2006.01); A61K 31/34 (2006.01); A61K 31/343 (2006.01); A61K 31/35 (2006.01); A61K 31/352 (2006.01); A61K 31/357 (2006.01); A61K 31/36 (2006.01); A61K 31/38 (2006.01); A61K 31/381 (2006.01); A61K 31/40 (2006.01); A61K 31/403 (2006.01); A61K 31/404 (2006.01); A61K 31/42 (2006.01); A61K 31/423 (2006.01); A61K 31/425 (2006.01); A61K 31/428 (2006.01); A61K 31/47 (2006.01); A61P 3/08 (2006.01); A61P 9/10 (2006.01); A61P 43/00 (2006.01); C07C 217/52 (2006.01); C07C 317/26 (2006.01); C07C 323/23 (2006.01); C07D 209/12 (2006.01); C07D 215/14 (2006.01); C07D 263/56 (2006.01); C07D 263/57 (2006.01); C07D 277/66 (2006.01); C07D 307/79 (2006.01); C07D 307/80 (2006.01); C07D 311/58 (2006.01); C07D 319/20 (2006.01); C07D 333/54 (2006.01)
CPC (source: EP US)
A61P 3/08 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07C 217/52 (2013.01 - EP US); C07D 215/14 (2013.01 - EP US); C07D 263/57 (2013.01 - EP US); C07D 277/66 (2013.01 - EP US); C07D 307/80 (2013.01 - EP US); C07C 2601/14 (2017.04 - EP US)
Designated contracting state (EPC)
DE FR GB IT
DOCDB simple family (publication)
WO 9414435 A1 19940707; AU 6080694 A 19940719; CA 2152912 A1 19940707; DE 69331954 D1 20020627; DE 69331954 T2 20021128; EP 0676960 A1 19951018; EP 0676960 A4 19951115; EP 0676960 B1 20020522; JP H08505847 A 19960625; US 5451596 A 19950919
DOCDB simple family (application)
US 9312638 W 19931229; AU 6080694 A 19931229; CA 2152912 A 19931229; DE 69331954 T 19931229; EP 94907116 A 19931229; JP 51548694 A 19931229; US 99781892 A 19921229