EP 0678017 A1 19951025 - LIPOSOME PREPARATION AND MATERIAL ENCAPSULATION METHOD.
Title (en)
LIPOSOME PREPARATION AND MATERIAL ENCAPSULATION METHOD.
Title (de)
HERSTELLUNG VON LIPOSOMEN UND VERFAHREN ZUR SUBSTANZVERKAPSELUNG.
Title (fr)
PROCEDE DE PREPARATION DE LIPOSOMES ET D'ENCAPSULATION DE MATIERES.
Publication
Application
Priority
- US 14809993 A 19931105
- US 9412350 W 19941103
Abstract (en)
[origin: WO9512387A1] The present invention relates to a method of producing liposomes useful for encapsulating and delivering a wide variety of biologically active materials. The invention provides liposomes and a production method which is simple, feasible and inexpensive for the large-scale commercial manufacturing of liposomes and encapsulated materials. The method involves the formation of a liposome dispersion in the absence of an organic solvent or detergent, one or several cycles of freezing and thawing the liposomes, and dehydration of the liposome dispersion to form a lipid powder. When desired, the lipid powder is hydrated in the presence of the biologically active material whereby the material is encapsulated in reconstituted liposomes. The method can also include combining the liposome dispersion with a bulking agent prior to the dehydration and formation of the lipid powder. The addition of the bulking agent facilitates the handling of the lipid powder as well as its rapid dispersal upon hydration.
IPC 1-7
IPC 8 full level
A61K 9/127 (2006.01)
CPC (source: EP US)
A61K 9/1277 (2013.01 - EP US); A61K 9/1278 (2013.01 - EP US)
Citation (search report)
See references of WO 9512387A1
Citation (examination)
- D. GLICK 'methods of biochemical analysis, vol. 3' 1988 , JOHN WILEY & SONS ,
- NEW YORK (US) see page 428, paragraph B. - page 431, paragraph C.
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9512387 A1 19950511; AT E164515 T1 19980415; AU 683957 B2 19971127; AU 8127394 A 19950523; CA 2153251 A1 19950511; CA 2153251 C 19980901; DE 69409361 D1 19980507; DE 69409361 T2 19981112; DK 0678017 T3 19981019; EP 0678017 A1 19951025; EP 0678017 B1 19980401; ES 2115343 T3 19980616; JP H08505882 A 19960625; US 5567433 A 19961022; US 6355267 B1 20020312
DOCDB simple family (application)
US 9412350 W 19941103; AT 95900452 T 19941103; AU 8127394 A 19941103; CA 2153251 A 19941103; DE 69409361 T 19941103; DK 95900452 T 19941103; EP 95900452 A 19941103; ES 95900452 T 19941103; JP 51330394 A 19941103; US 38161395 A 19950130; US 86801997 A 19970603