EP 0678095 A1 19951025 - CRYSTALLINE PENICILLIN DERIVATIVE, AND ITS PRODUCTION AND USE.
Title (en)
CRYSTALLINE PENICILLIN DERIVATIVE, AND ITS PRODUCTION AND USE.
Title (de)
KRISTALLINES PENICILLIN-DERIVAT, SEINE HERSTELLUNG UND VERWENDUNG.
Title (fr)
DERIVES CRISTALLIN DE PENICILLINE, SA PRODUCTION ET SON UTILISATION.
Publication
Application
Priority
- EP 93118016 A 19931106
- JP 9401855 W 19941102
Abstract (en)
[origin: WO9512601A1] Crystalline sodium 2 alpha -methyl-2 beta -(1,2,3-triazol-1-yl)-methylpenam-3 alpha -carboxylate-1,1-dioxide monohydrate (crystalline tazobactam sodium monohydrate) obtainable by adding to a concentrated aqueous solution of sodium 2 alpha -methyl-2 beta -(1,2,3-triazol-1-yl)-methylpenam-3 alpha -carboxylate-1,1-dioxide (tazobactam sodium) a solvent selected from acetone and ethanol in an amount corresponding to a solvent to water ratio of between about 95:5 and 99:1 v/v and crystallizing the desired product from the solvent mixture. The crystalline tazobactam sodium monohydrate exhibits a high beta -lactamase inhibitory activity in combination with beta -lactam antibiotics.
IPC 1-7
IPC 8 full level
A61K 31/43 (2006.01); A61K 31/431 (2006.01); A61P 31/04 (2006.01); C07D 499/00 (2006.01); C07D 499/86 (2006.01); C07D 499/87 (2006.01); C07D 499/897 (2006.01)
CPC (source: EP KR US)
A61P 31/04 (2017.12 - EP); C07D 499/00 (2013.01 - EP US); C07D 499/04 (2013.01 - KR)
Citation (search report)
See references of WO 9512601A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9512601 A1 19950511; AU 679800 B2 19970710; AU 8067094 A 19950523; CA 2145078 A1 19950507; CA 2145078 C 19990810; EP 0678095 A1 19951025; JP 3233407 B2 20011126; JP H08505645 A 19960618; KR 0180798 B1 19990320; KR 950703346 A 19950920; US 5763603 A 19980609
DOCDB simple family (application)
JP 9401855 W 19941102; AU 8067094 A 19941102; CA 2145078 A 19941102; EP 94931678 A 19941102; JP 51312495 A 19941102; KR 19950701154 A 19950325; US 40382995 A 19950321