EP 0681576 A1 19951115 - OXIME DERIVATIVES.
Title (en)
OXIME DERIVATIVES.
Title (de)
OXIME DERIVATE.
Title (fr)
DERIVES D'OXIME.
Publication
Application
Priority
- EP 94906140 A 19940125
- EP 9400186 W 19940125
- EP 93400212 A 19930128
Abstract (en)
[origin: WO9417054A1] The invention concerns oxime derivatives of formula (I) wherein R<4> includes hydrogen, carboxy, carbamoyl and (1-4C)alkyl; R<5> includes hydrogen, (1-4C)alkyl, (3-4C)alkenyl, (3-4C)alkynyl, (2-5C)alkanoyl and cyano-(1-4C)alkyl; Ar<1> is optionally-substituted phenylene or a heteroaryl diradical; A<1> is a direct link to X<1>, or A<1> is (1-4C)alkylene; X<1> is oxy, thio, sulphinyl or sulphonyl; Ar<2> includes optionally-substituted phenylene and thiophenediyl; R<1> is hydrogen, (2-5C)alkanoyl or benzoyl; and R<2> and R<3> together form a group of the formula -A<2>-X<2>-A<3>- which together with the carbon atom to which A<2> and A<3> are attached define a ring having 5 or 6 ring atoms, each of A<2> and A<3> is (1-3C)alkylene and X<2> includes oxy; or a pharmaceutically-acceptable salt thereof; processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.
IPC 1-7
IPC 8 full level
A61K 31/35 (2006.01); A61K 31/351 (2006.01); A61P 29/00 (2006.01); A61P 37/08 (2006.01); C07D 309/10 (2006.01); C07D 405/04 (2006.01); C07D 409/04 (2006.01)
CPC (source: EP)
A61P 29/00 (2017.12); A61P 37/08 (2017.12); C07D 309/10 (2013.01); C07D 409/04 (2013.01)
Citation (search report)
See references of WO 9417054A1
Designated contracting state (EPC)
CH DE FR GB IT LI
DOCDB simple family (publication)
WO 9417054 A1 19940804; AU 5998994 A 19940815; EP 0681576 A1 19951115; GB 9401271 D0 19940323; IL 108187 A0 19940412; JP H08505865 A 19960625; ZA 94107 B 19940728
DOCDB simple family (application)
EP 9400186 W 19940125; AU 5998994 A 19940125; EP 94906140 A 19940125; GB 9401271 A 19940124; IL 10818793 A 19931227; JP 51667394 A 19940125; ZA 94107 A 19940107