EP 0682523 A1 19951122 - USE OF TRICYCLIC ISOINDOLINONES AS ANTIVIRAL DRUGS, AND NEW, OPTICALLY ACTIVE ISOINDOLINONES.
Title (en)
USE OF TRICYCLIC ISOINDOLINONES AS ANTIVIRAL DRUGS, AND NEW, OPTICALLY ACTIVE ISOINDOLINONES.
Title (de)
VERWENDUNG VON TRIZYKLISCHEN ISOINDOLINONEN ALS ANTIVIRALE ARZNEIMITTEL UND NEUE, OPTISCH AKTIVE ISOINDOLINONE.
Title (fr)
UTILISATION D'ISO-INDOLINONES TRICYCLIQUES COMME MEDICAMENTS ANTIVIRAUX, ET NOUVELLES ISO-INDOLINONES OPTIQUEMENT ACTIVES.
Publication
Application
Priority
- DE 4106283 A 19910228
- DE 4117358 A 19910528
- EP 9200378 W 19920222
Abstract (en)
[origin: WO9215310A1] The invention concerns the use of tricyclic isoindole derivatives of general formula (I) to manufacture antiviral drugs. In formula (I), X stands for an oxygen or a sulphur atom, the imino group =NH or an N-C1-C5 alkylimino group, Y stands for an oxygen or a sulphur atom, or an NH-, C1-C5 alkylamino group, C1-C5-alkylocarbonylamino, sulphinyl or sulphonyl group, R stands for a hydrogen atom, an aliphatic residue with 1-9 carbon atoms, optionally substituted with phenyl, a phenyl ring, a carbocyclic ring with 7-15 carbon atoms or a heterocyclic ring system in which each ring has 5 or 6 atoms, R<1> and R<2> stand for a hydrogen atom, an aliphatic residue with 1-6 carbon atoms or C1-C6 alkoxy, C1-C6 alkymercapto, C1-C6 alkylsulphinyl, C1-C6 alkylsulphonyl, amino, C1-C6 alkylamino, di-C1-C6 alkylamino, sulphonamido, C1-C6 alkoxycarbonyl, carboxy, halogen, hydroxy, nitro, cyano, azido, phenyl or benzyloxy, R<3> and R<4> stand for hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkymercapto, amino, C1-C6 alkylamino, di-C1-C6 alkylamino, halogen, cyano, hydroxy, carboxy or C1-C6 alkoxycarbonyl. The invention also concerns the physiologically acceptable salts and the optically active derivatives of the compounds of the formula (I).
IPC 1-7
IPC 8 full level
A61K 31/495 (2006.01); A61K 31/505 (2006.01); A61K 31/535 (2006.01); A61K 31/54 (2006.01); A61K 31/55 (2006.01); A61P 31/12 (2006.01); C07D 487/04 (2006.01); C07D 498/04 (2006.01); C07D 513/04 (2006.01)
CPC (source: EP)
A61K 31/495 (2013.01); A61K 31/505 (2013.01); A61K 31/535 (2013.01); A61K 31/54 (2013.01); A61P 31/12 (2017.12); C07D 487/04 (2013.01); C07D 513/04 (2013.01)
Citation (search report)
See references of WO 9215310A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
WO 9215310 A1 19920917; AU 1251192 A 19921006; CA 2104963 A1 19920829; EP 0682523 A1 19951122; JP H06505017 A 19940609
DOCDB simple family (application)
EP 9200378 W 19920222; AU 1251192 A 19920222; CA 2104963 A 19920222; EP 92904953 A 19920222; JP 50491792 A 19920222