EP 0683778 A1 19951129 - HETEROAROMATIC COMPOUNDS WITH ANTIPSYCHOTIC ACTIVITY.
Title (en)
HETEROAROMATIC COMPOUNDS WITH ANTIPSYCHOTIC ACTIVITY.
Title (de)
HETEROAROMATISCHE VERBINDUNGEN MIT ANTIPSYCHOTISCHER AKTIVITÄT.
Title (fr)
COMPOSES HETEROAROMATIQUES A ACTIVITE ANTIPSYCHOTIQUE.
Publication
Application
Priority
- GB 9400265 W 19940210
- GB 9302622 A 19930210
Abstract (en)
[origin: WO9418196A1] The present invention relates to a group of piperazine and piperidine derivatives of formula (I), wherein Y is a heteroaryl group optionally substituted by one or more halogen, nitro, C1-6alkyl, C1-6alkoxy, aryloxy, arylC1-6alkylenoxy, hydroxy, S(O)nR<2> or S(O)nN(R<2>)2 where n is 0, 1 or 2, CN, CON(R<2>)2, COR<2>, CO2R<2>, CO-aryl, azido, -N(R<2>)2, -NR<2>N(R<2a>)2, -NR<2>N = C(R<2a>)2, -NR<2>(C = O)CH(N(R<2a>)2)R<2b>, -NR<2>(C = O)R<2a>, NR<2>CO2R<2a>, C1-6alkoxycarbonylamino or PhN = N; with the proviso that Y does not include benzisothiazolyls or benzisoxazolyis, V is O or S; Z is C1-8alkylene optionally interrupted by -O- or -S(O)n- where n is 0, 1 or 2, C2-8alkenylene or C2-8alkynylene; X is N, CR<3> or COR<3>; A is CR<4> or N; B is oxygen, NR<5> or S(O)n, where n is 0, 1 or 2; and R<1> is hydrogen or one or more halogen, hydroxy, nitro, CN, NR<6>2, C1-6alkoxy, aryloxy, arylC1-6alkylenoxy, or COR<6>, R, R<2>, R<2a>, R<2b>, R<3>, R<4>, R<5> and R<6>, are each hydrogen or C1-6alkyl; or a salt, solvate, N-oxide or physiologically functional derivative thereof, to processes for their preparation, to pharmaceutical compositions containing them and to their use in therapy, in particular in the treatment of psychotic disorders.
IPC 1-7
C07D 417/12; C07D 417/14; A61K 31/425; A61K 31/445; A61K 31/42; C07D 413/12; C07D 413/14
IPC 8 full level
A61K 31/495 (2006.01); A61P 25/18 (2006.01); C07D 275/04 (2006.01); C07D 417/12 (2006.01)
CPC (source: EP)
A61P 25/18 (2017.12); C07D 275/04 (2013.01); C07D 417/12 (2013.01)
Citation (search report)
See references of WO 9418196A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9418196 A1 19940818; AU 6005194 A 19940829; BG 99839 A 19960228; CA 2155758 A1 19940818; CN 1117731 A 19960228; CZ 204495 A3 19960313; EP 0683778 A1 19951129; FI 953777 A0 19950809; FI 953777 A 19950809; GB 9302622 D0 19930324; HU 9501881 D0 19950828; HU T73654 A 19960930; IL 108601 A0 19940530; JP H08506337 A 19960709; MX 9401080 A 19940831; SK 99195 A3 19951206; ZA 94891 B 19950810
DOCDB simple family (application)
GB 9400265 W 19940210; AU 6005194 A 19940210; BG 9983995 A 19950802; CA 2155758 A 19940210; CN 94191142 A 19940210; CZ 204495 A 19940210; EP 94906290 A 19940210; FI 953777 A 19950809; GB 9302622 A 19930210; HU 9501881 A 19940210; IL 10860194 A 19940209; JP 51781994 A 19940210; MX 9401080 A 19940210; SK 99195 A 19940210; ZA 94891 A 19940209