EP 0684828 A1 19951206 - EXPANSION OF STEM CELLS IN LONG TERM BONE MARROW CULTURES BY NEUTRALIZATION OF TGF--g(b).
Title (en)
EXPANSION OF STEM CELLS IN LONG TERM BONE MARROW CULTURES BY NEUTRALIZATION OF TGF--g(b).
Title (de)
VERMEHRUNG VON STAMMZELLEN IN LANGZEITKULTUREN VON KNOCHENMARKZELLEN DURCH NEUTRALISIERUNG VON T6F-BETA.
Title (fr)
EXPANSION DE CELLULES SOUCHES DANS LES CULTURES SUR UNE LONGUE DUREE DE M LLE OSSEUSE PAR NEUTRALISATION DU FACTEUR DE CROISSANCE TRANSFORMANT BETA.
Publication
Application
Priority
- US 9401634 W 19940215
- US 1955693 A 19930219
Abstract (en)
[origin: WO9418991A1] A method for expanding growth of hematopoietic stem cells in culture includes a step of admixing to the culture a TGF- beta antagonist such as a soluble TGF- beta receptor or a TGF- beta -neutralizing antibody. Also, treating an animal includes steps of admixing a TGF- beta antagonist to a culture of bone marrow cells to stimulate production of hematopoietic stem cells in the culture, and thereafter administering hematopoietic cells so produced to the animal. Also, a method for treating an animal includes steps of administering a TGF- beta antagonist to the animal.
IPC 1-7
IPC 8 full level
C12P 21/08 (2006.01); A61K 35/28 (2015.01); A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61K 38/22 (2006.01); A61K 39/395 (2006.01); A61P 7/00 (2006.01); C07K 16/22 (2006.01); C12N 5/0789 (2010.01); A61K 35/12 (2015.01)
CPC (source: EP)
A61K 35/28 (2013.01); A61K 38/179 (2013.01); A61P 7/00 (2017.12); C07K 16/22 (2013.01); C12N 5/0647 (2013.01); A61K 2035/124 (2013.01); C12N 2501/15 (2013.01); C12N 2501/39 (2013.01)
Designated contracting state (EPC)
DE ES FR GB IT
DOCDB simple family (publication)
WO 9418991 A1 19940901; CA 2155515 A1 19940901; EP 0684828 A1 19951206; EP 0684828 A4 19960807; JP H08509859 A 19961022
DOCDB simple family (application)
US 9401634 W 19940215; CA 2155515 A 19940215; EP 94910691 A 19940215; JP 51908594 A 19940215