Global Patent Index - EP 0684829 A4

EP 0684829 A4 19970521 - ROLE OF ATP-UBIQUITIN-DEPENDENT PROTEOLYSIS IN MHC-1 RESTRICTED ANTIGEN PRESENTATION AND INHIBITORS THEREOF.

Title (en)

ROLE OF ATP-UBIQUITIN-DEPENDENT PROTEOLYSIS IN MHC-1 RESTRICTED ANTIGEN PRESENTATION AND INHIBITORS THEREOF.

Title (de)

DIE ROLLE DER ATP-UBIQUITIN-ABHÄNGIGEN PROTEOLYSE IN DER MHC-1 ABHÄNGIGEN ANTIGENPRÄSENTATION UND ENTSPRECHENDE INHIBITOREN.

Title (fr)

ROLE DE LA PROTEOLYSE DEPENDANT DE L'UBIQUITINE ATP DANS LA PRESENTATION DE L'ANTIGENE RESTREINT CHM-1 ET INHIBITEURS UTILISES A CET EFFET.

Publication

EP 0684829 A4 19970521 (EN)

Application

EP 94908690 A 19940127

Priority

  • US 9401183 W 19940127
  • US 1606693 A 19930210

Abstract (en)

[origin: WO9417816A1] Described herein are methods and drugs that inhibit the processing of antigens for presentation by major histocompatibility complex class I molecules. Specifically, inhibitors of the ATP-ubiquitin dependent proteolytic pathway are described, which can inhibit MHC-I antigen presentation. These methods and drugs may be useful for the treatment of autoimmune diseases and for reducing rejection of organs and graft transplants.

IPC 1-7

A61K 38/00; A61K 38/43; A61K 38/55; A61K 39/00

IPC 8 full level

A61K 38/00 (2006.01); A61K 38/46 (2006.01); A61K 38/55 (2006.01); A61K 45/00 (2006.01); A61P 37/00 (2006.01); A61P 43/00 (2006.01); C07K 14/81 (2006.01)

CPC (source: EP)

A61K 38/55 (2013.01); A61P 37/00 (2017.12); A61P 43/00 (2017.12); C07K 14/81 (2013.01)

Citation (search report)

  • [X] WO 9220804 A1 19921126 - HARVARD COLLEGE [US]
  • [DX] GOLDBERG A.L. ET AL.: "Proteolysis, proteasomes and antigen presentation", NATURE, vol. 357, no. 6377, 4 June 1992 (1992-06-04), pages 375 - 379, XP002027833
  • [DX] DRISCOLL J ET AL: "AN ATP-STABILIZED INHIBITOR OF THE PROTEASOME IS A COMPONENT OF THE 1500-KDA UBIQUITIN CONJUGATE-DEGRADING COMPLEX.", PROC NATL ACAD SCI U S A 89 (11). 1992. 4986-4990, XP002027834
  • [PX] MICHALEK M T ET AL: "A ROLE FOR THE UBIQUITIN -DEPENDENT PROTEOLYTIC PATHWAY IN MHC CLASS I-RESTRICTED ANTIGEN PRESENTATION.", NATURE (LOND) 363 (6429). 1993. 552-554, XP002027835
  • [PX] MICHALEK M T ET AL: "A ROLE OF THE UBIQUITIN -DEPENDENT PROTEOLYTIC PATHWAY IN MHC CLASS I-RESTRICTED ANTIGEN PRESENTATION.", JOINT MEETING OF THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS AND THE CLINICAL IMMUNOLOGY SOCIETY, DENVER, COLORADO, USA, MAY 21-25, 1993. J IMMUNOL 150 (8 PART 2). 1993. 91A, XP002027836
  • See references of WO 9417816A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9417816 A1 19940818; AU 6169194 A 19940829; AU 676721 B2 19970320; CA 2155554 A1 19940818; EP 0684829 A1 19951206; EP 0684829 A4 19970521; JP H08507754 A 19960820

DOCDB simple family (application)

US 9401183 W 19940127; AU 6169194 A 19940127; CA 2155554 A 19940127; EP 94908690 A 19940127; JP 51818494 A 19940127