EP 0684837 A1 19951206 - METHODS FOR MODIFYING THE T CELL REPERTOIRE OF THE IMMUNE SYSTEM.
Title (en)
METHODS FOR MODIFYING THE T CELL REPERTOIRE OF THE IMMUNE SYSTEM.
Title (de)
METHODE ZUM MODIFIZIEREN DES T LYMPHOCYTEN REPERTOIRES DES IMMUNSYSTEMS.
Title (fr)
PROCEDES DE MODIFICATION DU REPERTOIRE DE LYMPHOCYTES T DU SYSTEME IMMUNITAIRE.
Publication
Application
Priority
- CA 9400083 W 19940217
- US 1864393 A 19930217
Abstract (en)
[origin: WO9419009A1] Compositions of subimmunogenic doses of substances which bind to T cell receptors on helper (TCR4) and/or suppressor cells (TCR8) are used to stabilize the immune system of an individual. The tolerogenic methods are useful in a variety of circumstances, including preventing graft rejection in transplantation, preventing and treating autoimmune diseases, inhibiting the development of acquired immunodeficiency diseases, and in desensitizing individuals to allergens. Preferred tolerogenic compounds include MHC class I and class II molecules, which may be allogeneic or xenogeneic to the individual being treated.
IPC 1-7
IPC 8 full level
C07K 14/74 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/70539 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9419009A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9419009 A1 19940901; AU 6034894 A 19940914; EP 0684837 A1 19951206
DOCDB simple family (application)
CA 9400083 W 19940217; AU 6034894 A 19940217; EP 94906809 A 19940217