EP 0684947 A1 19951206 - AMIDE COMPOUNDS WITH PHARMACOLOGICAL ACTIVITY.
Title (en)
AMIDE COMPOUNDS WITH PHARMACOLOGICAL ACTIVITY.
Title (de)
AMIDE VERBINDUNGEN MIT PHARMAZEUTISCHE WIRKUNG.
Title (fr)
COMPOSES D'AMIDE A ACTIVITE PHARMACOLOGIQUE.
Publication
Application
Priority
- GB 9400336 W 19940218
- GB 9303340 A 19930219
Abstract (en)
[origin: WO9419344A1] Compounds of formula X-NH-CO-Z and pharmaceutically acceptable salts thereof, and the use of a compound of said formula or a pharmaceutically salt thereof, wherein X is a monocyclic or polycyclic aromatic group, Z is of sub-formula (h), (j), or (k), wherein n<1> is 1, 2, 3 or 4; n<2> is 0, 1, 2, 3 or 4; n<3> is 2, 3, 4 or 5; q is 0, 1, 2 or 3; p is 0, 1 or 2; m is 0, 1 or 2; R5 is hydrogen, C1-12 alkyl, aralkyl or R5 is (CH2)z-R10 wherein z is 2 or 3 and R10 is selected from cyano, hydroxyl, C1-6 alkoxy, phenoxy, C(O)C1-6 alkyl, COC6H5, -CONR11R12, NR11COR12, SO2NR11R12 or NR11SO2R12 wherein R11 and R12 are hydrogen or C1-6 alkyl; or R5 is straight or branched chain alkylene of chain length 1-6 carbon atoms terminally substituted by aryl, 3 to 8 membered cycloalkyl, 3 to 8 membered heterocyclyl, 5 or 6 membered monocyclic heteroaryl or 9 or 10 membered fused bicyclic heteroaryl linked through carbon, C2-7 alkoxycarbonyl, or secondary or tertiary hydroxy substituted C1-6 alkyl; and R6, R7 and R8 are independently hydrogen or C1-6 alkyl; and R9 is hydrogen or C1-10 alkyl; and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders.
IPC 1-7
IPC 8 full level
C07D 295/20 (2006.01); A61K 31/165 (2006.01); A61K 31/39 (2006.01); A61K 31/42 (2006.01); A61K 31/423 (2006.01); A61K 31/425 (2006.01); A61K 31/428 (2006.01); A61K 31/4427 (2006.01); A61K 31/443 (2006.01); A61K 31/445 (2006.01); A61K 31/47 (2006.01); A61P 1/00 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 43/00 (2006.01); C07C 231/02 (2006.01); C07C 237/04 (2006.01); C07D 211/60 (2006.01); C07D 261/20 (2006.01); C07D 263/58 (2006.01); C07D 275/06 (2006.01); C07D 277/82 (2006.01); C07D 327/04 (2006.01); C07D 339/06 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 411/12 (2006.01); C07D 413/12 (2006.01); C07D 455/02 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01)
CPC (source: EP)
A61P 1/00 (2017.12); A61P 9/08 (2017.12); A61P 9/10 (2017.12); A61P 43/00 (2017.12); C07D 405/12 (2013.01)
Citation (search report)
See references of WO 9419344A1
Designated contracting state (EPC)
BE CH DE FR GB IT LI NL
DOCDB simple family (publication)
WO 9419344 A1 19940901; AU 6040994 A 19940914; EP 0684947 A1 19951206; GB 9303340 D0 19930407; JP H08507758 A 19960820
DOCDB simple family (application)
GB 9400336 W 19940218; AU 6040994 A 19940218; EP 94906959 A 19940218; GB 9303340 A 19930219; JP 51875594 A 19940218