EP 0687254 A1 19951220 - 4-AMINOPYRIDINES, THEIR PREPARATION AND THEIR USE AS ANTITHROMBOTIC AGENT
Title (en)
4-AMINOPYRIDINES, THEIR PREPARATION AND THEIR USE AS ANTITHROMBOTIC AGENT
Title (de)
4-AMINOPYRIDINE, IHRE HERSTELLUNG UND VERWENDUNG ALS ANTITHROMBOTISCHES MITTEL
Title (fr)
4-AMINOPYRIDINES, LEUR PREPARATION ET LEUR UTILISATION COMME AGENT ANTITHROMBOTIQUE
Publication
Application
Priority
- DE 4306873 A 19930305
- EP 9400609 W 19940302
Abstract (en)
[origin: WO9420468A1] Compounds of formula (i) in which R1 is an aryl, a heteroaryl or a cycloalkyl group which may, if desired, be substituted; AS is an amino-acid; n is 0 or 1; and R2 and R3 are the same or different and represent hydrogen atoms, alkyl, carboxy, alkyl or alkoxy carbonyl alkyl groups, or R2 and R3, together with the nitrogen atom to which they are bonded, form a heterocyclyl ring which may if desired also contain a second heteroatom and be substituted by alkyl, carboxy or alkoxy carbonyl groups; R4 and R5 are the same or different and are hydrogen atoms or alkyl groups; m &cir& _ is 0, 1 or 2; R6, R7, R8 and R9 are the same or different and are hydrogen or halogen atoms; and hydrates, solvates and physiological acceptable salts thereof. The invention also relates to the optically active forms, the racemates and the diastereomer mixtures of these compounds and a process for their production and medicaments containing these compounds, especially a process for the production of medicaments for the treatment of thrombo-embolic diseases.
IPC 1-7
IPC 8 full level
A61K 31/44 (2006.01); A61K 31/4409 (2006.01); A61P 7/02 (2006.01); C07D 213/74 (2006.01); C07K 5/06 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 7/02 (2017.12); C07D 213/74 (2013.01); C07K 5/06026 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9420468A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9420468 A1 19940915; AU 6282494 A 19940926; CA 2157215 A1 19940915; DE 4306873 A1 19940908; EP 0687254 A1 19951220; IL 108847 A0 19940624; JP H08509472 A 19961008; ZA 941522 B 19950904
DOCDB simple family (application)
EP 9400609 W 19940302; AU 6282494 A 19940302; CA 2157215 A 19940302; DE 4306873 A 19930305; EP 94910360 A 19940302; IL 10884794 A 19940303; JP 51955794 A 19940302; ZA 941522 A 19940304