EP 0687308 A4 19970709 - RECOMBINANT EPSTEIN-BARR VIRAL CAPSID ANTIGEN USEFUL IN DIAGNOSTIC METHOD
Title (en)
RECOMBINANT EPSTEIN-BARR VIRAL CAPSID ANTIGEN USEFUL IN DIAGNOSTIC METHOD
Title (de)
REKOMBINANTES KAPSIDANTIGEN DES EPSTEIN-BARR VIRUSES WELCHES NÜTZLICH IN EINER DIAGNOSTISCHEN METHODE IST
Title (fr)
ANTIGENE DE RECOMBINAISON DE LA CAPSIDE VIRALE DU VIRUS D'EPSTEIN-BARR, UTILE DANS UNE METHODE DIAGNOSTIQUE
Publication
Application
Priority
- US 9401775 W 19940223
- US 2195193 A 19930223
Abstract (en)
[origin: WO9419495A1] Recombinant EBV-gp125 protein is made in a baculovirus expression system in sufficient quantity and purity to enable its use in assays such as ELISAs for quantitative detection of EBV VCA-IgG and VCA-IgM antibodies. The recombinant gp125 protein is similar in size to EBV-gp125 viral capsid antigen isolated from EBV-infected human cell lines, and has similar sensitivity and specificity in immunological assays for VCA-Ig antibodies.
IPC 1-7
IPC 8 full level
G01N 33/53 (2006.01); C07K 14/05 (2006.01); C12N 15/09 (2006.01); C12Q 1/70 (2006.01); G01N 33/569 (2006.01); G01N 33/571 (2006.01)
CPC (source: EP KR)
C07K 4/02 (2013.01 - KR); C07K 14/005 (2013.01 - EP); C12P 21/06 (2013.01 - KR); C12Q 1/70 (2013.01 - KR); C12N 2710/14143 (2013.01 - EP); C12N 2710/16222 (2013.01 - EP)
Citation (search report)
- [Y] SCHUBACH, W.H. ET AL.: "Expression of Epstein-Barr virus Nuclear Antigen 2 in insect cells from a baculovirus vector", VIROLOGY, vol. 185, no. 1, November 1991 (1991-11-01), ORLANDO US, pages 428 - 431, XP000671826
- [Y] BAYLIS,S.A. ET AL.: "High-level expression of the Epstein-Barr Virus Alkaline desoxyribonuclease using a recombinant baculovirus: application to the diagnosis of nasopharyngeal carcinoma", VIROLOGY, vol. 181, no. 1, March 1991 (1991-03-01), ORLANDO US, pages 390 - 394, XP000671825
- [Y] NUEBLING, C.M. ET AL.: "Expression of Epstein-Barr virus membrane antigen gp350/220 in E. coli and in insect cells", VIROLOGY, vol. 191, no. 11, November 1992 (1992-11-01), ORLANDO US, pages 443 - 447, XP000673411
- [Y] FRAPPIER, L. & O'DONNELL M.: "Overproduction, purification, and characterization of EBNA1, the origin binding protein of Epstein-Barr virus", JOURNAL OF BIOLOGICAL CHEMISTRY (MICROFILMS), vol. 266, no. 12, 25 April 1991 (1991-04-25), MD US, pages 7819 - 7826, XP000673408
- See references of WO 9419495A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9419495 A1 19940901; AU 6269394 A 19940914; AU 674936 B2 19970116; CA 2150691 A1 19940901; EP 0687308 A1 19951220; EP 0687308 A4 19970709; JP H08507681 A 19960820; KR 960701218 A 19960224
DOCDB simple family (application)
US 9401775 W 19940223; AU 6269394 A 19940223; CA 2150691 A 19940223; EP 94910134 A 19940223; JP 51917194 A 19940223; KR 19950703301 A 19950809