EP 0688338 A1 19951227 - T CELL EPITOPES OF RYEGRASS POLLEN ALLERGEN
Title (en)
T CELL EPITOPES OF RYEGRASS POLLEN ALLERGEN
Title (de)
T-ZELL-EPITOPE DES ROGGENPOLLEN-ALLERGENS LOL pI
Title (fr)
DETERMINANTS ANTIGENIQUES DE LYMPHOCITES T DE L'ALLERGENE CONTENU DANS LE POLLEN DU RAY-GRASS
Publication
Application
Priority
- US 9402537 W 19940309
- US 3100193 A 19930312
Abstract (en)
[origin: WO9421675A2] The present invention provides isolated peptides of Lol p I, a major protein allergen of the species Lolium perenne. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen of Lol p I. The invention also provides modified peptides having similar or enhanced therapeutic or diagnostic properties as the corresponding, naturally-occurring allergen or portion thereof, but having additional properties, e.g., reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment and diagnosis of sensitivity to Lol p I or an allergen immunologically related to Lol p I in an individual (such as Dac g I, Poa p I, or Phl p I) also are provided. Compositions for therapeutic, diagnostic or reagent uses comprising one or more peptides of the invention are also provided.
IPC 1-7
C07K 7/08; C07K 15/10; C07K 15/28; C12N 15/29; C12N 15/70; A61K 38/00
IPC 8 full level
G01N 33/53 (2006.01); A61K 38/00 (2006.01); A61P 37/08 (2006.01); C07K 14/415 (2006.01); C07K 16/16 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12R 1/19 (2006.01)
CPC (source: EP)
A61P 37/08 (2017.12); C07K 14/415 (2013.01); C07K 16/16 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9421675A2
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9421675 A2 19940929; WO 9421675 A3 19941110; AU 6517594 A 19941011; AU 684501 B2 19971218; CA 2157596 A1 19940929; EP 0688338 A1 19951227; FI 954269 A0 19950912; FI 954269 A 19950912; IL 108940 A0 19940624; JP H08509966 A 19961022; NO 953571 D0 19950911; NO 953571 L 19951110; NZ 263913 A 19971024; ZA 941708 B 19941005
DOCDB simple family (application)
US 9402537 W 19940309; AU 6517594 A 19940309; CA 2157596 A 19940309; EP 94912761 A 19940309; FI 954269 A 19950912; IL 10894094 A 19940311; JP 52109694 A 19940309; NO 953571 A 19950911; NZ 26391394 A 19940309; ZA 941708 A 19940311