Global Patent Index - EP 0689547 A4

EP 0689547 A4 19981028 - CLONED HUMAN ALPHA1C ADRENERGIC RECEPTOR

Title (en)

CLONED HUMAN ALPHA1C ADRENERGIC RECEPTOR

Title (de)

KLONIERTER MENSCHLICHER ALPHA1C-ADRENERGISCHER REZEPTOR

Title (fr)

RECEPTEUR ALPHA1C-ADRENERGIQUE HUMAIN CLONE

Publication

EP 0689547 A4 19981028 (EN)

Application

EP 94912209 A 19940310

Priority

  • US 9402609 W 19940310
  • US 3284993 A 19930315

Abstract (en)

[origin: WO9421660A1] The human adrenergic receptor of the alpha1C subtype is cloned and used in an in vitro assay to screen for compounds that specifically bind to the human alpha1C adrenergic receptor, including compounds effective to reduce symptoms of benign prostatic hypertrophy. The invention includes the assay, the cloned human receptor used in the assay, an isolated human alpha1C adrenergic receptor free of other human proteins, and compounds identified through the use of this novel, cloned receptor, which selectively bind the human alpha1C adrenergic receptor.

IPC 1-7

C07H 21/00; C07K 14/00; C12N 15/00; C12P 21/00

IPC 8 full level

G01N 33/566 (2006.01); C07H 21/04 (2006.01); C07K 14/705 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); G01N 33/50 (2006.01); A61K 38/00 (2006.01); C12R 1/91 (2006.01)

CPC (source: EP)

C07K 14/70571 (2013.01); G01N 33/5008 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [E] WO 9408040 A1 19940414 - SYNAPTIC PHARMA CORP [US], et al
  • [E] WO 9410989 A1 19940526 - SYNAPTIC PHARMA CORP [US], et al
  • [DA] WO 9216213 A1 19921001 - MERCK & CO INC [US]
  • [DPA] WO 9323038 A1 19931125 - MERCK & CO INC [US], et al
  • [X] BRUNO J.F. ET AL.: "Molecular cloning and sequencing of a cDNA encoding a human alpha1A adrenergic receptor.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS., vol. 179, no. 3, 30 September 1991 (1991-09-30), pages 1485 - 1490, XP002059308
  • [PDX] HARISAWA A.: "Cloning, functional expression and tissue distribution of human cDNA for the alpha1C-adrenergic receptor.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 195, no. 2, 15 September 1993 (1993-09-15), pages 902 - 909, XP002059309
  • [PXPA] LEPOR H ET AL: "THE ALPHA-ADRENOCEPTOR SUBTYPE MEDIATING THE TENSION OF HUMAN PROSTATIC SMOOTH MUSCLE", THE PROSTATE, vol. 22, no. 4, 16 June 1993 (1993-06-16), pages 301 - 307, XP002047748
  • [A] MELLIN T N ET AL: "AZASTEROIDS AS INHIBITORS OF TESTOSTERONE 5ALPHA-REDUCTASE IN MAMMALIAN SKIN", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 44, no. 2, February 1993 (1993-02-01), pages 121 - 131, XP002028037
  • [A] SCHWINN D A & LOMASNEY J W: "Pharmacological characterization of cloned alpha 1-adrenoceptor subtypes: selective antagonists suggest the existence of a fourth subtype", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 227, no. 4, 1 December 1992 (1992-12-01), pages 433 - 436, XP002075428
  • See references of WO 9421660A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9421660 A1 19940929; AU 6445394 A 19941011; AU 685789 B2 19980129; CA 2158345 A1 19940929; EP 0689547 A1 19960103; EP 0689547 A4 19981028; JP H08508163 A 19960903

DOCDB simple family (application)

US 9402609 W 19940310; AU 6445394 A 19940310; CA 2158345 A 19940310; EP 94912209 A 19940310; JP 52111594 A 19940310