Global Patent Index - EP 0690716 A4

EP 0690716 A4 19970502 - OLIGONUCLEOTIDES MODIFIED TO IMPROVE STABILITY AT ACID pH

Title (en)

OLIGONUCLEOTIDES MODIFIED TO IMPROVE STABILITY AT ACID pH

Title (de)

MODIFIZIERTE OLIGONUKLEOTIDE ZUR VERBESSERUNG DER STABILITÄT IM SAUREM PH-BEREICH

Title (fr)

OLIGONUCLEOTIDES MODIFIES POUR AMELIORER LA STABILITE A pH ACIDE

Publication

EP 0690716 A4 19970502 (EN)

Application

EP 94906041 A 19940105

Priority

  • US 9400157 W 19940105
  • US 110993 A 19930106

Abstract (en)

[origin: WO9415619A1] Acid resistant oligonucleotides modified by alkylation at the 2'-O-position are suitable for oral administration. Orally acceptable formulations prepared with the disclosed modified oligonucleotides as active ingredients are also provided.

IPC 1-7

A61K 31/70; C07H 21/02

IPC 8 full level

C07H 21/04 (2006.01); A61K 31/70 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); C07H 21/00 (2006.01)

CPC (source: EP KR)

A61K 31/70 (2013.01 - EP KR); A61P 31/12 (2017.12 - EP); A61P 35/00 (2017.12 - EP); C07H 21/00 (2013.01 - EP); C07H 21/02 (2013.01 - KR)

Citation (search report)

  • [X] EP 0260032 A2 19880316 - AJINOMOTO KK [JP]
  • [A] US 4511713 A 19850416 - MILLER PAUL S [US], et al
  • [X] H.INOUE ET AL.: "Synthesis and Hybridization Studies on two Complementary Nona(2'-O-methyl)ribonucleotides.", NUCLEIC ACIDS RESEARCH, vol. 15, no. 15, 1987, OXFORD GB, pages 6131 - 6148, XP000570336
  • [X] I.HIRAO ET AL.: "Synthesis and Properties of an Initiation Codon Analog Consisting of 2'-O-Methyl Nucleotides.", NUCLEOSIDES AND NUCLEOTIDES, vol. 9, no. 8, 1990, pages 1113 - 1122, XP000609767
  • [X] S.SHIBAHARA ET AL.: "Sire-Directed Cleavage of RNA.", NUCLEIC ACIDS RESEARCH, vol. 15, no. 11, 1987, OXFORD GB, pages 4403 - 4415, XP000609038
  • [A] R.KIERZEK ET AL.: "Some Steric Aspects of Synthesis of Oligoribonucleotides by Phosphoramidite Approach on Solid Support.", BULLETIN OF THE POLISH ACADEMY OF SCIENCES, vol. 35, no. 11-12, 1987, pages 507 - 516, XP000609848
  • See references of WO 9415619A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9415619 A1 19940721; AU 5992494 A 19940815; AU 692143 B2 19980604; CA 2152672 A1 19940721; CN 1118140 A 19960306; EP 0690716 A1 19960110; EP 0690716 A4 19970502; IL 108206 A0 19940412; JP H08505396 A 19960611; KR 960700062 A 19960119; NZ 261253 A 19970727

DOCDB simple family (application)

US 9400157 W 19940105; AU 5992494 A 19940105; CA 2152672 A 19940105; CN 94191223 A 19940105; EP 94906041 A 19940105; IL 10820693 A 19931228; JP 51618894 A 19940105; KR 19950702783 A 19950706; NZ 26125394 A 19940105