EP 0691979 A1 19960117 - NOVEL 5'-SUBSTITUTED NUCLEOSIDES AND OLIGOMERS PRODUCED THEREFROM
Title (en)
NOVEL 5'-SUBSTITUTED NUCLEOSIDES AND OLIGOMERS PRODUCED THEREFROM
Title (de)
NEUE 5'-SUBSTITUIERTE NUCLEOSIDE UND DARAUS HERGESTELLTE OLIGOMERE
Title (fr)
NOUVEAUX NUCLEOSIDES SUBSTITUES EN POSITION 5' ET OLIGOMERES OBTENUS A PARTIR DE CEUX-CI
Publication
Application
Priority
- US 9402993 W 19940321
- US 4075093 A 19930331
Abstract (en)
[origin: WO9422890A1] Disclosed are novel 5'-substituted nucleosides and oligonucleotide analog compounds prepared therefrom having from 2 to about 60 bases and having an internucleoside backbone containing one or more 3'-O-PO2H-O-5'-CR1R2- internucleoside linkages instead of the naturally occurring backbone of phosphodiester internucleoside linkages. The present invention also discloses a method of synthesizing oligonucleotide compounds having from 2 to about 60 bases and having an internucleoside backbone containing one or more 3'-O-PO2H-O-5'-CR1R2 internucleoside linkages instead of the naturally occurring backbone of phosphodiester internucleoside linkages, this process comprising preparation of 5'-substituted nucleoside compounds, for example, as illustrated in Figure 1, and utilizing them as synthons in automated DNA synthesizers. Oligonucleotide analogs of the present invention are useful as nuclease resistant, sequence specific antisense compounds.
IPC 1-7
C07H 21/00; C07H 19/04; C07H 19/10; C07H 19/20; C07H 21/04; A61K 31/70
IPC 8 full level
C12N 15/09 (2006.01); A61K 31/70 (2006.01); A61K 31/7042 (2006.01); A61K 31/7052 (2006.01); A61K 31/7064 (2006.01); A61K 31/7068 (2006.01); A61K 31/7072 (2006.01); A61K 31/7076 (2006.01); A61K 31/708 (2006.01); A61K 31/7088 (2006.01); A61P 35/00 (2006.01); C07H 19/04 (2006.01); C07H 19/06 (2006.01); C07H 19/10 (2006.01); C07H 19/16 (2006.01); C07H 19/20 (2006.01); C07H 21/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07H 19/04 (2013.01); C07H 19/06 (2013.01); C07H 19/10 (2013.01); C07H 19/16 (2013.01); C07H 19/20 (2013.01); C07H 21/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9422890 A1 19941013; AU 6449294 A 19941024; CA 2159632 A1 19941013; EP 0691979 A1 19960117; HU 9501994 D0 19950928; JP H08508490 A 19960910
DOCDB simple family (application)
US 9402993 W 19940321; AU 6449294 A 19940321; CA 2159632 A 19940321; EP 94912265 A 19940321; HU 9501994 A 19940321; JP 52213194 A 19940321