EP 0695346 A1 19960207 - HUMAN ERYTHROID PROGENITOR CELL POPULATION
Title (en)
HUMAN ERYTHROID PROGENITOR CELL POPULATION
Title (de)
HUMANE BLUTBILDENDE VORLÄUFERZELLPOPULATION
Title (fr)
POPULATION DE CELLULES SOUCHES ERYTHROIDES HUMAINES
Publication
Application
Priority
- US 9404124 W 19940414
- US 5243393 A 19930423
Abstract (en)
[origin: WO9425571A1] The invention provides a method of preparing from hematopoietic cells a population of cells enriched for erythroid progenitor cells (BFU-E) in which up to 100 % of the colony-forming units are BFU-E. The method entails separating hematopoietic progenitor cells on the basis of binding to a specific cell surface antigen such as CD34, and separation of erythroid progenitor cells based on binding to a lectin such as Ulex europaeus agglutinin. After separation of the erythroid progenitors, the lectin may be eluted off the cells by incubation with excess sugar, such as fucose, which competes for the cell-binding site on the lectin. The invention also provides a method of treatment for human patients having an erythroid disorder via administration of a cell population enriched for human erythroid progenitor cells. Also provided are diagnostic methods based on the enriched cell population.
IPC 1-7
IPC 8 full level
A61K 35/14 (2006.01); A61K 35/28 (2015.01); A61K 35/407 (2006.01); A61K 35/54 (2006.01); A61P 7/06 (2006.01); C12N 5/078 (2010.01); A61K 35/12 (2015.01)
CPC (source: EP)
A61K 35/28 (2013.01); A61P 7/06 (2017.12); C12N 5/0641 (2013.01); A61K 2035/124 (2013.01); C12N 2503/02 (2013.01)
Citation (search report)
See references of WO 9425571A1
Designated contracting state (EPC)
DE FR GB IT
DOCDB simple family (publication)
WO 9425571 A1 19941110; AU 6559094 A 19941121; CA 2160871 A1 19941110; EP 0695346 A1 19960207; IL 106255 A0 19931115; JP H08509377 A 19961008
DOCDB simple family (application)
US 9404124 W 19940414; AU 6559094 A 19940414; CA 2160871 A 19940414; EP 94913419 A 19940414; IL 10625593 A 19930706; JP 52433094 A 19940414