EP 0695368 A4 19960508 - RANDOM CHEMISTRY FOR THE GENERATION OF NEW COMPOUNDS
Title (en)
RANDOM CHEMISTRY FOR THE GENERATION OF NEW COMPOUNDS
Title (de)
ZUFALLSPROZESS FÜR DIE CHEMISCHE DARSTELLUNG NEUER VERBINDUNGEN
Title (fr)
PROCEDE ALEATOIRE DE PRODUCTION DE NOUVEAUX COMPOSES CHIMIQUES
Publication
Application
Priority
- US 9404314 W 19940419
- US 4926893 A 19930419
Abstract (en)
[origin: WO9424314A1] Methods for the generation of new compounds are disclosed. The present invention eliminates the need to know in advance the structure or chemical composition of a compound having a desired property. The disclosure of the present invention provides that diversity of unknown compounds may be produced by "random" chemistry, and such a diversity of unknown compounds may be screened for one or more desired properties to detect the presence of suitable compounds. In one aspect, a starting group of organic compounds is caused to undergo a series of chemical reactions to create a diversity of new organic compounds that are screened for the presence of organic compounds having the desired property. In another aspect of the present invention, a diversity of compounds is generated from a group of substrates which are subjected to a group of enzymes representing a diversity of catalytic activities.
IPC 1-7
IPC 8 full level
C07B 61/00 (2006.01); C07K 1/04 (2006.01); C12N 9/00 (2006.01); C12N 15/10 (2006.01); C12P 1/00 (2006.01); C12P 19/34 (2006.01); C12P 21/00 (2006.01); C12Q 1/68 (2006.01); C12Q 1/6811 (2018.01)
CPC (source: EP)
C07K 1/047 (2013.01); C12N 9/0002 (2013.01); C12N 15/1093 (2013.01); C12P 1/00 (2013.01); C12P 19/34 (2013.01); C12Q 1/6811 (2013.01); C40B 40/10 (2013.01); C40B 50/06 (2013.01)
Citation (search report)
- [X] M. EIGEN ET AL.: "Ursprung der genetischen Information", SPEKTRUM DER WISSENSCHAFT, no. 6, HEIDELBERG, BRD, pages 37 - 56
- [X] B. GONG ET AL.: "A chromogenic assay for screening large antibody libraries", J. AM. CHEM. SOC., vol. 114, no. 4, 12 February 1992 (1992-02-12), AM. CHEM. SOC., US, pages 1486 - 1487
- [X] R.A. HOUGHTEN ET AL.: "Generation and use of synthetic peptide libraries for basic research and drug discovery", NATURE, vol. 354, 7 November 1991 (1991-11-07), MACMILLAN JOURNALS LTD., LONDON,UK, pages 84 - 86, XP000371737, DOI: doi:10.1038/354084a0
- [X] LAM K S ET AL: "A NEW TYPE OF SYNTHETIC PEPTIDE LIBRARY FOR IDENTIFYING LIGAND-BINDING ACTIVITY", NATURE, vol. 354, no. 6348, 7 November 1991 (1991-11-07), pages 82 - 84, XP000371736
- [X] C. TUERK AND L GOLD: "Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage tç DNA polymerase", SCIENCE, vol. 249, 3 August 1990 (1990-08-03), AAAS,WASHINGTON,DC,US, pages 505 - 510, XP002547963, DOI: doi:10.1126/science.2200121
- [Y] D.S. TAWFIK ET AL.: "catELISA: A facile general route to catalytic antibodies", PROC. NATL.ACAD SCI., vol. 90, NATL. ACAD SCI.,WASHINGTON,DC,US;, pages 373 - 377, XP002044712, DOI: doi:10.1073/pnas.90.2.373
- [Y] Y.-C.J. CHEN ET AL.: "Catalytic antibodies from combinatorial libraries", J. AM. CHEM. SOC., vol. 115, no. 1, 13 January 1993 (1993-01-13), AM. CHEM. SOC.,US, pages 357 - 358
- [Y] S.A. KAUFFMAN: "Autocatalytic sets of proteins", J. THEORETICAL BIOLOGY, vol. 119, no. 1, 7 March 1986 (1986-03-07), ACADEMIC PRESS INC., LONDON, UK, pages 1 - 24, XP000564567
- [PX] KAUFFMAN, STUART: "Random Chemistry", BER. BUNSEN-GES. PHYS. CHEM. (1994), 98(9), 1142-7 CODEN: BBPCAX;ISSN: 0005-9021
- See references of WO 9424314A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9424314 A1 19941027; AU 6815894 A 19941108; CA 2160457 A1 19941027; EP 0695368 A1 19960207; EP 0695368 A4 19960508; JP H09500007 A 19970107
DOCDB simple family (application)
US 9404314 W 19940419; AU 6815894 A 19940419; CA 2160457 A 19940419; EP 94916542 A 19940419; JP 52355294 A 19940419