EP 0696271 A1 19960214 - CYCLOOXYGENASE AND 5-LIPOXYGENASE INHIBITING HYDROXAMIC ACID DERIVATIVES
Title (en)
CYCLOOXYGENASE AND 5-LIPOXYGENASE INHIBITING HYDROXAMIC ACID DERIVATIVES
Title (de)
CYCLOOXYGENASE UND 5-LIPOXYGENASE HEMMENEDE HYDROXAMSÄUREDERIVATE
Title (fr)
DERIVES DE L'ACIDE HYDROXAMIQUE INHIBITEURS DE LA CYCLOOXYGENASE ET DE LA 5-LIPOXYGENASE
Publication
Application
Priority
- GB 9308652 A 19930427
- GB 9400885 W 19940426
Abstract (en)
[origin: WO9425430A1] The present invention is concerned with novel hydroxamic acid derivatives of formula (I) and their use in medical therapy, particularly in the prophylaxis or treatment of clinical conditions for which an inhibitor of the lipoxygenase or cyclooxygenase mediated arachidonic acid metabolic pathway is indicated. The invention also relates to pharmaceutical formulations and processes for the preparation of compounds according to the invention. In formula (I) Y is -C(Q)=C(Q')-((E)- or (Z)-) wherein Q and Q' are independently selected from hydrogen, C1-4 alkyl and halo, or Y is -CC-; R is C1-4 alkyl optionally substituted by fluoro; D is C1-4 alkyl, phenyl or -NR<1>R<2> (wherein R<1> and R<2> are independently selected from hydrogen, C1-4 alkyl, and phenyl); and ring A and ring B are each optionally substituted by a group or groups independently selected from halo, cyano, nitro, hydroxy, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, -C(O)OR<3>, -C(O)R<3>, -C(O)NR<3>R<4>, -NR<3>R<4>, -NHCOR<3>, -NHCO2R<3>, -NHC(O)NR<3>R<4>, -NHSO2R<3>, -SO2NR<3>R<4> (wherein R<3> and R<4> are independently selected from hydrogen, C1-4 alkyl and phenyl), and -S(O)nR<5> (wherein n is an integer of from 0 to 2 and R<5> is C1-4 alkyl, C6-10 aryl (for example, phenyl or naphthyl), or C8-12 aralkyl).
IPC 1-7
IPC 8 full level
A61K 31/165 (2006.01); A61K 31/17 (2006.01); A61K 31/195 (2006.01); A61K 31/215 (2006.01); A61K 31/235 (2006.01); A61K 31/275 (2006.01); A61P 1/00 (2006.01); A61P 1/04 (2006.01); A61P 3/06 (2006.01); A61P 11/00 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07C 259/06 (2006.01); C07C 275/64 (2006.01); C07C 311/16 (2006.01); C07C 317/40 (2006.01); C07C 323/40 (2006.01)
CPC (source: EP)
A61P 1/00 (2017.12); A61P 1/04 (2017.12); A61P 3/06 (2017.12); A61P 11/00 (2017.12); A61P 29/00 (2017.12); A61P 43/00 (2017.12); C07C 259/06 (2013.01); C07C 275/64 (2013.01)
Citation (search report)
See references of WO 9425430A1
Citation (examination)
- EP-A- 0 196 184
- EP-A- 0 299 761
- EP-A- 0 384 594
- WO-A-92/10469
- US-A- 5 169 854
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9425430 A1 19941110; AU 6574994 A 19941121; EP 0696271 A1 19960214; GB 9308652 D0 19930609; JP H08509487 A 19961008; ZA 942911 B 19951026
DOCDB simple family (application)
GB 9400885 W 19940426; AU 6574994 A 19940426; EP 94913699 A 19940426; GB 9308652 A 19930427; JP 52401894 A 19940426; ZA 942911 A 19940426