EP 0696285 A1 19960214 - WATER SOLUBLE DERIVATIVES OF CAMPTOTHECIN AND THEIR USE AS ANTITUMOR AGENTS
Title (en)
WATER SOLUBLE DERIVATIVES OF CAMPTOTHECIN AND THEIR USE AS ANTITUMOR AGENTS
Title (de)
WASSERLOESLICHE CAMPTOTHECINDERIVATE UND IHRE VERWENDUNG ALS ANTITUMORMITTEL
Title (fr)
DERIVES HYDROSOLUBLES DE CAMPTOTHECINE ET LEUR UTILISATION COMME AGENTS ANTITUMORAUX
Publication
Application
Priority
- US 9404681 W 19940428
- US 5458593 A 19930429
- US 8104293 A 19930622
Abstract (en)
[origin: WO9425466A1] The present invention relates to water soluble, camptothecin derivatives of formula (I), wherein: n represents the integer 1 or 2; and i) R<1> represents: hydrogen, lower alkyl, (C3-7)cycloalkyl, (C3-7)cycloalkyl lower alkyl, lower alkenyl, hydroxy lower alkyl, amino lower alkyl, lower alkylamino lower alkyl, amino lower alkyl, lower alkoxy lower alkyl or (CH2)tAr wherein: t is 0 to 5 and Ar represents phenyl, furyl, pyridyl, N-methylpyrrolyl, imidazolyl; or phenyl, furyl, pyridyl, N-methylpyrrolyl, imidazolyl, with one or more substituents independently selected from hydroxy, methoxy, halogen, and amino; and R<2> represents: diphenylmethyl or (CH2)tAr; or ii) R1 and R2 taken together with the linking nitrogen represent: N-tetrahydroquinolyl or N-tetrahydroisoquinolyl; and the pharmaceutically acceptable salts and solvates thereof, their use in the treatment of tumors and methods of their preparation.
IPC 1-7
IPC 8 full level
A61K 31/47 (2006.01); A61P 35/00 (2006.01); C07D 317/66 (2006.01); C07D 319/18 (2006.01); C07D 491/22 (2006.01)
IPC 8 main group level
CPC (source: EP)
A61P 35/00 (2017.12); C07D 317/66 (2013.01); C07D 319/18 (2013.01)
Citation (search report)
See references of WO 9425466A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9425466 A1 19941110; AP 9400638 A0 19951028; AU 6777194 A 19941121; CA 2161681 A1 19941110; EP 0696285 A1 19960214; IL 109470 A0 19940731; IS 4152 A 19941030; JP H08509740 A 19961015; MY 141374 A 20100416; PE 52894 A1 19950106
DOCDB simple family (application)
US 9404681 W 19940428; AP 9400638 A 19940428; AU 6777194 A 19940428; CA 2161681 A 19940428; EP 94915931 A 19940428; IL 10947094 A 19940428; IS 4152 A 19940425; JP 52454094 A 19940428; MY PI9401039 A 19940427; PE 24106194 A 19940427