EP 0697874 A1 19960228 - METHODS OF AFFECTING THE GROWTH OF LIVING TISSUE IN MAMMALS AND COMPOUNDS AND COMPOSITIONS THEREFOR
Title (en)
METHODS OF AFFECTING THE GROWTH OF LIVING TISSUE IN MAMMALS AND COMPOUNDS AND COMPOSITIONS THEREFOR
Title (de)
VERFAHREN ZUR BEEINFLUSSUNG DES WACHSTUMS VON LEBENDEM GEWEBE IN SÄUGETIEREN UND VERBINDUNGEN UND PRÄPARATE HIERFÜR
Title (fr)
PROCEDES POUR INFLUER SUR LA CROISSANCE DES TISSUS VIVANTS CHEZ LES MAMMIFERES ET COMPOSES ET COMPOSITIONS CORRESPONDANTES
Publication
Application
Priority
- US 9403559 W 19940331
- US 4049893 A 19930331
Abstract (en)
[origin: WO9422455A1] Methods and compositions for affecting the growth of cells of living tissue in mammals. The compositions comprise a metabolic inhibitor of a glycolytic pathway of cells and/or an agent which causes an increase in the concentration of intracellular sodium, and a physiologically acceptable carrier. The compositions are administered to the patient either alone or in combination with a growth factor. Depending on the desired route of administration, the compositions are formulated to have either a very high water solubility or low water solubility. The highly water soluble compositions may be orally administered, whereas the low water soluble compositions may be applied directly to the location of a wound. The compositions are administered to deliver growth factor to a wound or to absorb growth factor present in the body to prevent overstimulation of the wound response. The compositions are particularly useful as wound healing materials, including wounds associated with abnormally proliferating and/or migrating cells, for example, smooth muscle cells, which are associated with restenosis.
IPC 1-7
A61K 31/70; A61K 31/72; A61K 31/715; A61K 31/725; A61K 31/735
IPC 8 full level
A61K 45/00 (2006.01); A61K 31/00 (2006.01); A61K 31/70 (2006.01); A61K 31/715 (2006.01); A61K 38/18 (2006.01); A61K 47/48 (2006.01); A61P 43/00 (2006.01); C08B 37/16 (2006.01)
CPC (source: EP)
A61K 31/00 (2013.01); A61K 31/7004 (2013.01); A61K 31/715 (2013.01); A61K 38/18 (2013.01); A61K 47/6951 (2017.07); A61P 43/00 (2017.12); B82Y 5/00 (2013.01)
Citation (search report)
See references of WO 9422455A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9422455 A1 19941013; AU 6553994 A 19941024; BR 9405858 A 19951212; CA 2159717 A1 19941013; EP 0697874 A1 19960228; JP H08511041 A 19961119
DOCDB simple family (application)
US 9403559 W 19940331; AU 6553994 A 19940331; BR 9405858 A 19940331; CA 2159717 A 19940331; EP 94913338 A 19940331; JP 52238694 A 19940331