EP 0698039 A1 19960228 - PEPTIDES FOR SUPPRESSION OF MYELOID PROGENITOR CELL PROLIFERATION AND TREATMENT OF SEPTIC SHOCK
Title (en)
PEPTIDES FOR SUPPRESSION OF MYELOID PROGENITOR CELL PROLIFERATION AND TREATMENT OF SEPTIC SHOCK
Title (de)
PEPTIDE FÜR DIE UNTERDRÜCKUNG DER TEILUNG VON MYELOIDEN VORLÄUFERZELLEN UND DIE BEHANDLUNG DES SEPTISCHEN SCHOCKS
Title (fr)
PEPTIDES DE SUPPRESSION DE LA PROLIFERATION DE CELLULES SOUCHES MYELOIDES ET DE TRAITEMENT DU CHOC SEPTIQUE
Publication
Application
Priority
- US 9405773 W 19940518
- US 6572293 A 19930520
Abstract (en)
[origin: WO9428013A1] Peptides containing the sequence Ala-Lys-Pro-Arg have suppressive effects on the proliferation of a broad range of myelopoietic progenitor cells. In a preferred embodiment, the peptide has the sequence Glu-Thr-Val-Ile-Met-Lys-Ala-Lys-Pro-Arg-Ala-Asn-Phe-Pro. The peptides of the present invention are useful in the treatment of myelopoietic hyperproliferative disorders, and in protecting myeloid cells from damage induced by chemotherapy and radiation. Peptides containing the sequence Ala-Lys-Pro-Arg are also useful in the treatment of endotoxin-induced septic shock.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61P 7/00 (2006.01); A61P 9/00 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/47 (2006.01)
CPC (source: EP)
A61P 7/00 (2017.12); A61P 9/00 (2017.12); C07K 7/08 (2013.01); C07K 14/4703 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9428013A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB IE IT LI NL SE
DOCDB simple family (publication)
WO 9428013 A1 19941208; CA 2162610 A1 19941208; EP 0698039 A1 19960228; JP H08510745 A 19961112
DOCDB simple family (application)
US 9405773 W 19940518; CA 2162610 A 19940518; EP 94916812 A 19940518; JP 50086694 A 19940518