EP 0698100 A1 19960228 - HYBRID PICORNAVIRUSES EXPRESSING CHLAMYDIAL EPITOPES
Title (en)
HYBRID PICORNAVIRUSES EXPRESSING CHLAMYDIAL EPITOPES
Title (de)
HYBRIDE PICORNAVIREN DIE CHLAMYDIA-EPITOPEN EXPRIMIEREN
Title (fr)
PICORNAVIRUS HYBRIDES EXPRIMANT DES EPITOPES CHLAMYDIENS
Publication
Application
Priority
- CA 9400262 W 19940512
- US 6097893 A 19930513
Abstract (en)
[origin: WO9426900A2] Hybrid picornaviruses expressing chlamydial epitopes from the major outer membrane protein of Chlamydia trachomatis in a functional form are described. The hybrid viruses grow to high titre in cell culture and when administered to mammals induce an immune response against both the picornavirus and C. trachomatis. The antisera from immunised mammals neutralised both homotypic and heterotypic serovars of C. trachomatis. The hybrid picornaviruses have utility as vaccines and as tools for the generation of immunological reagents. Methods for modifying surface exposed loops of known sequences to produce hybrid proteins are described.
IPC 1-7
C12N 15/31; C12N 7/00; C12N 15/86; A61K 39/118; A61K 39/13; C12P 21/08; G01N 33/571; C12N 15/62
IPC 8 full level
C07K 14/295 (2006.01); C12N 15/31 (2006.01); C12N 15/32 (2006.01); C12N 15/62 (2006.01); A61K 39/00 (2006.01)
CPC (source: EP US)
C07K 14/295 (2013.01 - EP); C12N 15/62 (2013.01 - EP); A61K 39/00 (2013.01 - EP US); C07K 2319/00 (2013.01 - EP); C07K 2319/40 (2013.01 - EP); Y02A 50/30 (2018.01 - EP)
Designated contracting state (EPC)
DE FR GB
DOCDB simple family (publication)
WO 9426900 A2 19941124; WO 9426900 A3 19950216; AU 6718394 A 19941212; CA 2162664 A1 19941124; EP 0698100 A1 19960228
DOCDB simple family (application)
CA 9400262 W 19940512; AU 6718394 A 19940512; CA 2162664 A 19940512; EP 94915485 A 19940512