Global Patent Index - EP 0701563 A4

EP 0701563 A4 19970702 - GENE TRANSFER FOR TREATING A CONNECTIVE TISSUE OF A MAMMALIAN HOST

Title (en)

GENE TRANSFER FOR TREATING A CONNECTIVE TISSUE OF A MAMMALIAN HOST

Title (de)

GEN TRANSFER ZUR BEHANDLUNG VON BINDEGEWEBE EINES SÄUGETIERWIRTES

Title (fr)

TRANSFERT GENIQUE DESTINE AU TRAITEMENT DE TISSUS CONJONCTIFS CHEZ UN MAMMIFERE HOTE

Publication

EP 0701563 A4 19970702 (EN)

Application

EP 94910861 A 19940307

Priority

  • US 9402414 W 19940307
  • US 2775093 A 19930308

Abstract (en)

[origin: WO9420517A1] The subject invention concerns a method of introducing at least one gene encoding a product into at least one cell of a connective tissue of a mammalian host for use in treating the mammalian host including employing recombinant techniques to produce a DNA vector molecule which contains the gene encoding for the product and infecting the connective cell of the mammalian host using the DNA vector molecule using the gene coding for the product. A method is provided for introducing at least one gene encoding a product into at least one cell of a connective tissue of a mammalian host employing non-viral means. A method to produce an animal model for the study of connective tissue pathology is also disclosed. Additionally, this invention provides a method of using in vivo a gene encoding an extracellular interleukin-1 binding domain of an interleukin-1 receptor.

IPC 1-7

C07H 15/12; C07H 7/00; A01K 43/04; A61K 31/70; A61K 38/00; C12P 19/34; C12N 15/00; A01N 63/00

IPC 8 full level

A01K 67/027 (2006.01); A61K 31/70 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 38/22 (2006.01); A61K 38/46 (2006.01); A61K 38/55 (2006.01); A61K 48/00 (2006.01); A61P 43/00 (2006.01); C07H 21/04 (2006.01); C07K 14/545 (2006.01); C07K 14/715 (2006.01); C12N 5/077 (2010.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01)

CPC (source: EP)

A61K 48/00 (2013.01); A61P 43/00 (2017.12); C07K 14/545 (2013.01); C07K 14/715 (2013.01); C12N 15/8509 (2013.01); A01K 2207/15 (2013.01); A01K 2217/00 (2013.01); A01K 2217/05 (2013.01); A01K 2267/025 (2013.01); A01K 2267/03 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [DXY] WO 9211359 A1 19920709 - UNIV PITTSBURGH [US]
  • [Y] WO 9207943 A1 19920514 - SOMATIX THERAPY CORP [US], et al
  • [Y] EP 0176170 A1 19860402 - MERIEUX INST [FR]
  • [X] BANDARA, G. ET AL: "Gene transfer to synoviocytes: prospects for gene treatment of arthritis", DNA CELL BIOL. (1992), 11(3), 227-31 CODEN: DCEBE8;ISSN: 1044-5498, 1992, XP000671125
  • [X] G. BANDARA ET AL.: "Intraarticular expression of IRAP by gene transfer", ARTHRITIS AND RHEUMATISM, vol. 35, no. 9, September 1992 (1992-09-01), pages S193, XP000563856
  • [X] EVANS C H ET AL: "SYNOVIAL CELL TRANSPLANTS FOR GENE TRANSFER TO JOINTS.", FIRST INTERNATIONAL CONGRESS OF THE CELL TRANSPLANT SOCIETY, PITTSBURGH, PENNSYLVANIA, USA, MAY 31-JUNE 3, 1992. TRANSPLANT PROC 24 (6). 1992. 2966. CODEN: TRPPA8 ISSN: 0041-1345, XP000577114
  • [X] EVANS C H ET AL.: "Gene transfer to joints for arthritis therapy", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 16, no. F, April 1992 (1992-04-01), pages 46, XP000566580
  • [DY] XIANG GAO ET AL.: "A novel cationic liposome reagent for efficient transfection of mammalian cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 179, no. 1, 30 August 1991 (1991-08-30), ORLANDO, FL US, pages 280 - 285, XP000572654
  • [PX] BANDARA, G. ET AL: "Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer", PROC. NATL. ACAD. SCI. U. S. A. (1993), 90(22), 10764-8 CODEN: PNASA6;ISSN: 0027-8424, 1993, XP002029933
  • [PX] PAUL D. ROBBINS ET AL.: "Retroviral vectors for use in human gene therapy for cancer, Gaucher disease, and arthritis", ANNAL NEW YORK ACADEMY OF SCIENCES, vol. 716, June 1993 (1993-06-01), pages 26 - 29, XP000565748
  • [PX] HUNG, G.L. ET AL: "Suppression of intra-articular responses to interleukin-1 by transfer of the interleukin-1 receptor antagonist gene to synovium", GENE THER. (1994), 1(1), 64-9 CODEN: GETHEC, 1994, XP000671119
  • [PX] BLAKE J. ROESSLER ET AL.: "Adenoviral-mediated gene transfer to rabbit synovium in vivo", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 92, no. 2, August 1993 (1993-08-01), pages 1085 - 1092, XP000671409
  • See references of WO 9420517A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9420517 A1 19940915; CA 2157782 A1 19940915; EP 0701563 A1 19960320; EP 0701563 A4 19970702; JP H08511507 A 19961203

DOCDB simple family (application)

US 9402414 W 19940307; CA 2157782 A 19940307; EP 94910861 A 19940307; JP 52022294 A 19940307