EP 0702557 A1 19960327 - THERAPEUTIC INHIBITOR OF VASCULAR SMOOTH MUSCLE CELLS
Title (en)
THERAPEUTIC INHIBITOR OF VASCULAR SMOOTH MUSCLE CELLS
Title (de)
EIN INHIBITOR FÜR GLATTE GEFÄSSMUSKELZELLEN FÜR THERAPEUTISCHE NUTZUNG
Title (fr)
INHIBITEURS DES CELLULES DES MUSCLES VASCULAIRES LISSES, A USAGE THERAPEUTIQUE
Publication
Application
Priority
- US 9405266 W 19940512
- US 6245193 A 19930513
Abstract (en)
[origin: WO9426291A1] Sustained release dosage forms of TGF-beta activators and TGF-beta production stimulators are employed to maintain or increase vessel lumen diameter in a diseased or injured vessel of a mammal. Conditions such as restenosis following angioplasty, vascular bypass grafts, transplanted organs, atherosclerosis or hypertension are characterized by a reduced vessel lumen diameter. In a preferred embodiment of the invention, TGF-beta activators and production stimulators inhibit abnormal proliferation of smooth muscle cells. Free TGF-beta activators or production stimulators that are not characterized by an undesirable systemic toxicity profile at a prophylactic dose may be used in conjunction with the sustained release dosage forms described herein for prophylactic purposes with respect to disease and trauma states involving proliferation and/or migration of vascular smooth muscle cells over time.
IPC 1-7
IPC 8 full level
A61K 9/16 (2006.01); A61K 31/00 (2006.01); A61K 31/135 (2006.01); A61K 31/138 (2006.01); A61K 31/337 (2006.01); A61K 31/40 (2006.01); A61K 31/4025 (2006.01); A61K 31/4035 (2006.01); A61K 31/407 (2006.01); A61K 38/22 (2006.01); A61K 47/48 (2006.01); A61P 9/08 (2006.01); A61P 43/00 (2006.01)
CPC (source: EP US)
A61K 31/00 (2013.01 - EP US); A61K 31/135 (2013.01 - EP); A61K 31/138 (2013.01 - EP); A61K 31/337 (2013.01 - EP); A61K 31/40 (2013.01 - EP); A61K 31/4025 (2013.01 - EP); A61K 31/4035 (2013.01 - EP); A61K 31/407 (2013.01 - EP); A61K 47/51 (2017.08 - EP); A61K 47/6809 (2017.08 - EP); A61K 47/6817 (2017.08 - EP); A61K 47/6831 (2017.08 - EP); A61K 47/6843 (2017.08 - EP); A61K 47/6927 (2017.08 - EP); A61K 47/6933 (2017.08 - EP); A61K 47/6957 (2017.08 - EP); A61P 9/08 (2018.01 - EP); A61P 43/00 (2018.01 - EP); G01N 2800/323 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9426291 A1 19941124; AT E401911 T1 20080815; CA 2162587 A1 19941124; CA 2162587 C 20080708; DE 69435120 D1 20080904; EP 0702557 A1 19960327; EP 0702557 A4 19980603; EP 1510220 A1 20050302; EP 1510220 B1 20080723; JP H08510209 A 19961029
DOCDB simple family (application)
US 9405266 W 19940512; AT 04077621 T 19940512; CA 2162587 A 19940512; DE 69435120 T 19940512; EP 04077621 A 19940512; EP 94916743 A 19940512; JP 52361394 A 19940512