EP 0702724 A1 19960327 - MENGOVIRUS AS A VECTOR FOR EXPRESSION OF FOREIGN POLYPEPTIDES
Title (en)
MENGOVIRUS AS A VECTOR FOR EXPRESSION OF FOREIGN POLYPEPTIDES
Title (de)
MENGOVIRUS ALS VEKTOR FÜR DIE EXPRESSION VON FREUNDPOLYPEPTIDEN
Title (fr)
MENGOVIRUS UTILISE COMME VECTEUR D'EXPRESSION DE POLYPEPTIDES ETRANGERS
Publication
Application
Priority
- US 9406177 W 19940603
- US 9053193 A 19930603
Abstract (en)
[origin: WO9429472A2] This invention relates to attenuated recombinant mengoviruses expressing a heterologous amino acid sequence. The recombinant mengoviruses can express amino acid sequences comprising epitopes of various viral pathogens and are useful as live vaccines for humans and animals against these pathogens. Consequently, this invention also relates to vaccines comprising these recombinant mengoviruses or proteins thereof, cells infected with the recombinant mengoviruses, nucleic acid derived from the recombinant mengoviruses, and methods of inducing an immune response. The invention is exemplified by a recombinant mengovirus comprising amino acids 299-466 of gp120 of the MN isolate of HIV-I.
IPC 1-7
C12N 15/86; C07K 14/085; C07K 14/16; C07K 14/145; A61K 39/12; A61K 39/125; A61K 39/21; A61K 39/205; A61K 39/295
IPC 8 full level
C12N 15/09 (2006.01); A61K 39/12 (2006.01); A61P 31/12 (2006.01); C07H 21/04 (2006.01); C07K 14/08 (2006.01); C07K 14/085 (2006.01); C07K 14/145 (2006.01); C07K 14/155 (2006.01); C07K 14/16 (2006.01); C07K 19/00 (2006.01); C12N 5/10 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01); C12P 21/02 (2006.01); A61K 39/00 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP)
A61P 31/12 (2018.01); C07K 14/005 (2013.01); C12N 15/86 (2013.01); A61K 39/00 (2013.01); C07K 2319/033 (2013.01); C07K 2319/40 (2013.01); C07K 2319/50 (2013.01); C12N 2740/16122 (2013.01); C12N 2760/10022 (2013.01); C12N 2760/20122 (2013.01); C12N 2770/32222 (2013.01); C12N 2770/32243 (2013.01); C12N 2840/203 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9429472 A2 19941222; WO 9429472 A3 19950216; CA 2164297 A1 19941222; EP 0702724 A1 19960327; JP H08511165 A 19961126
DOCDB simple family (application)
US 9406177 W 19940603; CA 2164297 A 19940603; EP 94923174 A 19940603; JP 50192295 A 19940603