EP 0703901 A1 19960403 - 1-SUBSTITUTED ISATIN AND OXINDOLE DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE
Title (en)
1-SUBSTITUTED ISATIN AND OXINDOLE DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE
Title (de)
1-SUBSTITUIERTE ISATIN- UND OXOINDOLDERIVATE ALS ACETYLCHOLESTERINESTERASEHEMMER
Title (fr)
DERIVES DE L'ISATINE A SUBSTITUTION 1 ET DE L'OXINDOLE UTILES COMME INHIBITEURS DE L'ACETYLCHOLINESTERASE
Publication
Application
Priority
- SE 9400448 W 19940513
- SE 9302080 A 19930616
Abstract (en)
[origin: WO9429272A1] The present invention relates to novel compounds having general formula (1) wherein n is 3, 4, 5, 6 or 7; X represents one or more substituents independently selected from hydrogen, lower alkyl, aryl, lower alkoxy, halogen, trifluoromethyl, nitro, -NHCOR where R is lower alkyl or aryl, -NR1R2 where R1 and R2 are independently hydrogen or lower alkyl or together form a ring, or cycloalkyl, cycloalkenyl or bicycloalkyl either optionally further substituted by lower alkyl; Y is (a) or (b) where R3 and R4 are independently hydrogen, lower alkyl, lower alkoxy or together form a cyclic acetal; Z is lower alkyl; and W represents one or more substituents independently selected from hydrogen, lower alkyl, lower alkoxy or halogen; stereo and optical isomers and racemates thereof where such isomers exist, as well as pharmaceutically acceptable acid addition salts thereof and solvates thereof having therapeutic activity, intermediates for their preparation, processes for their preparation, pharmaceutical formulations containing said compounds and medicinal use of said compounds.
IPC 1-7
IPC 8 full level
A61K 31/40 (2006.01); A61K 31/403 (2006.01); A61K 31/404 (2006.01); A61K 31/4427 (2006.01); A61K 31/445 (2006.01); A61P 25/00 (2006.01); A61P 25/28 (2006.01); C07D 209/34 (2006.01); C07D 209/38 (2006.01); C07D 401/04 (2006.01); C07D 491/10 (2006.01); C07D 491/113 (2006.01)
CPC (source: EP)
A61P 25/00 (2017.12); A61P 25/28 (2017.12); C07D 209/34 (2013.01); C07D 209/38 (2013.01); C07D 491/10 (2013.01)
Citation (search report)
See references of WO 9429272A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9429272 A1 19941222; AU 7010894 A 19950103; CA 2164119 A1 19941222; EP 0703901 A1 19960403; FI 956074 A0 19951218; FI 956074 A 19951218; IS 4167 A 19941217; JP H08511515 A 19961203; NO 955074 D0 19951214; NO 955074 L 19960207; SE 9302080 D0 19930616
DOCDB simple family (application)
SE 9400448 W 19940513; AU 7010894 A 19940513; CA 2164119 A 19940513; EP 94919032 A 19940513; FI 956074 A 19951218; IS 4167 A 19940518; JP 50164295 A 19940513; NO 955074 A 19951214; SE 9302080 A 19930616