EP 0707493 A1 19960424 - INHIBITORS AND TARGET MOLECULE CO-LOCALIZATION
Title (en)
INHIBITORS AND TARGET MOLECULE CO-LOCALIZATION
Title (de)
KOLOKALISATION VON ZIELMOLEKUEL UND SEINEM INHIBITOR
Title (fr)
CO-LOCALISATION D'UNE MOLECULE CIBLE ET DE SES INHIBITEURS
Publication
Application
Priority
- US 9413798 W 19941202
- US 18582794 A 19940124
Abstract (en)
[origin: WO9519788A1] The invention provides mechanisms for the co-localization in a living cell of a target molecule and of an inhibitor for the target molecule. The invention also provides novel chimeric tRNA<LYS>-ribozyme molecules that compete effectiely with tRNA<LYS> for HIV-1 reverse transcriptase binding sites. The chimeric human tRNA<LYS>-ribozymes inhibit reverse HIV transcription by delivering inhibitors such as ribozymes of HIV-1 reverse transcriptase directly to the virion particle and render it non-functional. The chimeric molecules of the invention thus serve as highly specific non-toxic therapeutic agents and vaccines for viral, including lentiviral, infections. These chimeric molecules also reveal a novel, site specific RNA cleaving activity of HIV-1.
IPC 1-7
IPC 8 full level
C12N 9/22 (2006.01); C12N 15/113 (2010.01); C12Q 1/70 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01)
CPC (source: EP)
C12N 9/22 (2013.01); C12N 15/1132 (2013.01); C12Q 1/703 (2013.01); A61K 38/00 (2013.01); A61K 39/00 (2013.01); C07K 2319/00 (2013.01); C12N 2310/111 (2013.01); C12N 2310/121 (2013.01)
Designated contracting state (EPC)
DE FR GB
DOCDB simple family (publication)
WO 9519788 A1 19950727; AU 1333595 A 19950808; AU 692208 B2 19980604; CA 2157015 A1 19950727; EP 0707493 A1 19960424; EP 0707493 A4 19990331
DOCDB simple family (application)
US 9413798 W 19941202; AU 1333595 A 19941202; CA 2157015 A 19941202; EP 95904785 A 19941202