Global Patent Index - EP 0707493 A4

EP 0707493 A4 19990331 - INHIBITORS AND TARGET MOLECULE CO-LOCALIZATION

Title (en)

INHIBITORS AND TARGET MOLECULE CO-LOCALIZATION

Title (de)

KOLOKALISATION VON ZIELMOLEKUEL UND SEINEM INHIBITOR

Title (fr)

CO-LOCALISATION D'UNE MOLECULE CIBLE ET DE SES INHIBITEURS

Publication

EP 0707493 A4 19990331 (EN)

Application

EP 95904785 A 19941202

Priority

  • US 9413798 W 19941202
  • US 18582794 A 19940124

Abstract (en)

[origin: WO9519788A1] The invention provides mechanisms for the co-localization in a living cell of a target molecule and of an inhibitor for the target molecule. The invention also provides novel chimeric tRNA<LYS>-ribozyme molecules that compete effectiely with tRNA<LYS> for HIV-1 reverse transcriptase binding sites. The chimeric human tRNA<LYS>-ribozymes inhibit reverse HIV transcription by delivering inhibitors such as ribozymes of HIV-1 reverse transcriptase directly to the virion particle and render it non-functional. The chimeric molecules of the invention thus serve as highly specific non-toxic therapeutic agents and vaccines for viral, including lentiviral, infections. These chimeric molecules also reveal a novel, site specific RNA cleaving activity of HIV-1.

IPC 1-7

A61K 38/43; A61K 47/48; C12N 9/22; C12N 5/22; C12Q 1/25

IPC 8 full level

C12N 9/22 (2006.01); C12N 15/113 (2010.01); C12Q 1/70 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01)

CPC (source: EP)

C12N 9/22 (2013.01); C12N 15/1132 (2013.01); C12Q 1/703 (2013.01); A61K 38/00 (2013.01); A61K 39/00 (2013.01); C07K 2319/00 (2013.01); C12N 2310/111 (2013.01); C12N 2310/121 (2013.01)

Citation (search report)

  • [XY] WO 9324133 A1 19931209 - HOPE CITY [US], et al
  • [Y] WO 9323569 A1 19931125 - RIBOZYME PHARM INC [US]
  • [X] EP 0387775 A1 19900919 - BOEHRINGER INGELHEIM INT [DE]
  • [DXY] SULLENGER B A ET AL: "TETHERING RIBOZYMES TO A RETROVIRAL PACKAGING SIGNAL FOR DESTRUCTION OF VIRAL RNA", SCIENCE, vol. 262, 3 December 1993 (1993-12-03), pages 1566 - 1569, XP000567869
  • [A] ROSSI J J ET AL: "RIBOZYMES AS ANTI-HIV-1 THERAPEUTIC AGENTS: PRINCIPLES, APPLICATIONS, AND PROBLEMS", AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 8, no. 2, February 1992 (1992-02-01), pages 183 - 189, XP002026934
  • [DXP] HERSCHLAG D ET AL: "AN RNA CHAPERONE ACTIVITY OF NON-SPECIFIC RNA BINDING PROTEINS IN HAMMERHEAD RIBOZYME CATALYSIS", EMBO JOURNAL, vol. 13, no. 12, 15 June 1994 (1994-06-15), pages 2913 - 2924, XP000567895
  • See also references of WO 9519788A1

Designated contracting state (EPC)

DE FR GB

DOCDB simple family (publication)

WO 9519788 A1 19950727; AU 1333595 A 19950808; AU 692208 B2 19980604; CA 2157015 A1 19950727; EP 0707493 A1 19960424; EP 0707493 A4 19990331

DOCDB simple family (application)

US 9413798 W 19941202; AU 1333595 A 19941202; CA 2157015 A 19941202; EP 95904785 A 19941202