Title (en)

METHODS AND COMPOSITIONS FOR DETECTING AND TREATING MYCOBACTERIAL INFECTIONS USING AN inhA GENE

Title (de)

METHODEN UND ZUSAMMENSETZUNG ZUR FESTSTELLUNG UND BEHANDLUNG VON MYKOBAKTERIELLEN INFEKTIONEN UNTER VERWENDUNG EINES inhA GENES

Title (fr)

PROCEDES ET COMPOSITIONS DE DETECTION ET DE TRAITEMENT DES INFECTIONS MYCOBACTERIENNES AU MOYEN D'UN GENE inhA

Publication

EP 0707496 A1 19960424 (EN)

Application

EP 94917378 A 19940512

Priority

• NZ 24762093 A 19930513
• US 9405344 W 19940512
• US 6240993 A 19930514

Abstract (en)

[origin: WO9426312A1] The embodiments of the invention are based upon the identification and characterization of genes that determine mycobacterial resistance to the antibiotic isoniazid (INH) and its analogs. These genes, termed inhA, encode a polypeptide, InhA, that is the target of action of mycobacteria for isoniazid. The sequences of wild-type INH-sensitive as well as allelic or mutant INH-resistant inhA genes and their operons are provided. Also provided are isolated InhA polypeptides of both the INH-resistant and INH-sensitive types.

IPC 1-7

A61K 48/00; C07H 21/00; C12P 19/34

IPC 8 full level

C12N 15/09 (2006.01); A61K 8/00 (2006.01); A61K 31/70 (2006.01); A61K 38/00 (2006.01); A61K 39/04 (2006.01); A61P 31/04 (2006.01); A61Q 17/00 (2006.01); C07H 21/04 (2006.01); C12N 1/21 (2006.01); C12N 9/02 (2006.01); C12N 9/08 (2006.01); C12P 7/40 (2006.01); C12Q 1/68 (2006.01)

CPC (source: EP)

A61K 39/04 (2013.01); A61P 31/04 (2017.12); C12N 9/001 (2013.01); C12N 9/0065 (2013.01); C12Q 1/689 (2013.01); C12Q 2600/156 (2013.01)

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9426312 A1 19941124; AU 690121 B2 19980423; AU 6912194 A 19941212; CA 2162868 A1 19941124; EP 0707496 A1 19960424; EP 0707496 A4 19971112; JP H09501823 A 19970225

DOCDB simple family (application)

US 9405344 W 19940512; AU 6912194 A 19940512; CA 2162868 A 19940512; EP 94917378 A 19940512; JP 52572394 A 19940512