EP 0708764 A1 19960501 - ENANTHIOSELECTIVE PREPARATION OF THIAZOLE DERIVATIVES
Title (en)
ENANTHIOSELECTIVE PREPARATION OF THIAZOLE DERIVATIVES
Title (de)
ENANTIOSELEKTIVE HERSTELLUNG VON THIAZOLE-DERIVATEN
Title (fr)
PREPARATION ENANTIOSELECTIVE DE DERIVES DE THIAZOLE
Publication
Application
Priority
- IB 9400062 W 19940406
- US 9283293 A 19930716
Abstract (en)
[origin: WO9502585A1] An enanthioselective process for preparing the compounds of formulas (I) and (II) from the prochiral ketone precursor of the alcohol of formula (I). The compounds of formulas (I) and (II) are thus obtained in substantially enantiomerically pure form by reducing the ketone with a borane reducing agent in the presence of a chiral oxazaborolidine catalyst.
IPC 1-7
IPC 8 full level
A61K 31/42 (2006.01); A61P 3/08 (2006.01); A61P 3/10 (2006.01); B01J 31/14 (2006.01); C07B 53/00 (2006.01); C07B 61/00 (2006.01); C07D 277/24 (2006.01); C07D 417/04 (2006.01); C07F 5/02 (2006.01)
CPC (source: EP)
A61P 3/08 (2017.12); A61P 3/10 (2017.12); C07D 277/24 (2013.01); C07D 417/04 (2013.01); C07F 5/02 (2013.01)
Citation (search report)
See references of WO 9502585A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9502585 A1 19950126; CA 2167287 A1 19950126; EP 0708764 A1 19960501; FI 960180 A0 19960115; FI 960180 A 19960115; JP H08507310 A 19960806
DOCDB simple family (application)
IB 9400062 W 19940406; CA 2167287 A 19940406; EP 94910017 A 19940406; FI 960180 A 19960115; JP 52039894 A 19940406