EP 0709373 B1 20011017 - PYRROLIDINE DERIVATIVE
Title (en)
PYRROLIDINE DERIVATIVE
Title (de)
PYRROLIDIN DERIVATE
Title (fr)
DERIVE DE PYRROLIDINE
Publication
Application
Priority
- JP 18293093 A 19930723
- JP 9401208 W 19940722
Abstract (en)
[origin: EP0709373A1] A novel pyrrolidine derivative represented by general formula (1) or a pharmaceutically acceptable salt thereof, having a prolyl endopeptidase inhibitor activity and promising as an active ingredient of an antiamnetic. In said formula R1 represents (1) lower alkyl (C1-C6) or (2) an optionally substituted hydrocarbon ring group (a 3- to 15-membered monocyclic or fused-ring group); n and m represent each an integer and the sum of them represents an integer of 0 to 2; X and E represent each oxygen. NR' (wherein R' represents hydrogen or C1-C6 alkyl), sulfur, phenylene, CH=CH or CH2; A represents an amino acid or imino acid residue wherein the functional group(s) may be substituted, or a glycine residue wherein the amino group may be substituted; and Y1 represents C3-C8 cycloalkyl. <CHEM>
IPC 1-7
C07D 207/08; C07D 207/16; C07D 401/10; C07D 401/12; C07D 403/06; C07D 405/12; C07D 409/12; A61K 31/40; A61K 31/44; A61K 31/455; C07D 403/12
IPC 8 full level
C07D 207/08 (2006.01); C07D 207/16 (2006.01); C07D 401/06 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/06 (2006.01); C07D 405/10 (2006.01); C07D 409/10 (2006.01); C07D 521/00 (2006.01)
CPC (source: EP US)
C07D 207/08 (2013.01 - EP US); C07D 207/16 (2013.01 - EP US); C07D 231/12 (2013.01 - EP US); C07D 233/56 (2013.01 - EP US); C07D 249/08 (2013.01 - EP US); C07D 401/06 (2013.01 - EP US); C07D 401/10 (2013.01 - EP US); C07D 401/12 (2013.01 - EP US); C07D 401/14 (2013.01 - EP US); C07D 405/06 (2013.01 - EP US); C07D 405/10 (2013.01 - EP US); C07D 409/10 (2013.01 - EP US)
Designated contracting state (EPC)
DE FR GB IT
DOCDB simple family (publication)
EP 0709373 A1 19960501; EP 0709373 A4 19960925; EP 0709373 B1 20011017; DE 69428703 D1 20011122; DE 69428703 T2 20020529; US 5756763 A 19980526; US 5965556 A 19991012; WO 9503277 A1 19950202
DOCDB simple family (application)
EP 94921799 A 19940722; DE 69428703 T 19940722; JP 9401208 W 19940722; US 1953598 A 19980205; US 58150796 A 19960111