EP 0710234 A1 19960508 - ISOFLAVONE DERIVATIVES
Title (en)
ISOFLAVONE DERIVATIVES
Title (de)
ISOFLAVON-DERIVATE
Title (fr)
DERIVES DE L'ISOFLAVONE
Publication
Application
Priority
- HU 9302083 A 19930720
- HU 9400028 W 19940719
Abstract (en)
[origin: WO9503293A1] The present invention relates to isoflavone, isoflavan-4-one and isoflavane derivatives of general formula (I), their salts, pharmaceutical compositions containing the compounds of general formula (I), and to a process for preparing the same. In general formula (I), if n is 0, R<5> and R<6> together stand for an oxo group and the dotted line means a double bond, R<1> represents C1-18alkyl substituted by alkylcarbonyl, carboxy, sulfonic acid, hydroxy, phenoxy, piperidino, morpholino or piridino or by a (C1-4alkyl)2N-(CH2)mCO(CH2)p- or by (C1-4alkyl)2N-(CH2)mOCO(CH2)p- group; or stands for C3-6cycloalkyl or cycloalkenyl; or if n is 1, R<5> and R<6> together stand for an oxo group and the dotted line means a double bond, R<1> represents C1-18alkyl optionally substituted by alkyl-carbonyl, alkoxycarbonyl, carboxy, sulfonic acid, hydroxy, phenoxy, piperidino, morpholino or piridino or by a (C1-4alkyl)2N-(CH2)mCO(CH2)p- group; or stands for C3-6-cycloalkyl or cycloalkenyl or C2-6alkenyl; or if n is 0 or 1, R<5> and R<6> together stand for an oxo group or stand separately for hydrogen and the dotted line does not mean a chemical bond, R<1> represents C1-18alkyl optionally substituted by alkyl-carbonyl, alkoxycarbonyl, carboxy, sulfonic acid, hydroxy, alkoxy, phenyl optionally substituted by a halo atom, phenoxy, piperidino, morpholino or piridino or by a (C1-4alkyl)2N-(CH2)mCO(CH2)p- group; or stands for C3-6-cycloalkyl or C2-6alkenyl; or R stands for C1-8alkyl, halogen, C1-4alkoxymethyl, C2-5-acyloxymethyl, or hydroxymethyl; R<4> stands for hydrogen or C1-4alkyl; R<2> and R<3> stand for hydrogen or C1-6alkoxy; R<5> and R<6> together stand for an oxo group or separately stand for hydrogen; the dotted line means a double bond being optionally present; n is 0 or 1; m is an integer from 1 to 4; and p is an integer from 1 to 4. The compounds of general formula (I) can be used for the prevention and treatment of osteoporosis. They are prepared by methods well known in the organic chemistry.
IPC 1-7
IPC 8 full level
C07D 311/36 (2006.01); C07D 311/38 (2006.01)
CPC (source: EP KR)
C07D 311/36 (2013.01 - EP KR); C07D 311/38 (2013.01 - EP KR)
Citation (search report)
See references of WO 9503293A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9503293 A1 19950202; AU 7236794 A 19950220; CA 2167597 A1 19950202; CA 2167714 A1 19950202; CN 1129445 A 19960821; EP 0710234 A1 19960508; HU 9302083 D0 19931028; HU T68558 A 19950628; KR 960703888 A 19960831
DOCDB simple family (application)
HU 9400028 W 19940719; AU 7236794 A 19940719; CA 2167597 A 19940718; CA 2167714 A 19940719; CN 94193107 A 19940719; EP 94921776 A 19940719; HU 9302083 A 19930720; KR 19960700364 A 19960119