EP 0710237 A1 19960508 - QUINOLIZIDINES WITH CALCIUM CHANNEL ANTAGONISTIC ACTIVITY
Title (en)
QUINOLIZIDINES WITH CALCIUM CHANNEL ANTAGONISTIC ACTIVITY
Title (de)
QUINOLIZIDINE MIT CALCIUM ANTAGONISTISCHER WIRKUNG
Title (fr)
QUINOLIZIDINES A ACTIVITE ANTAGONISTE DES CANAUX A CALCIUM
Publication
Application
Priority
- EP 9402298 W 19940711
- GB 9314973 A 19930720
Abstract (en)
[origin: WO9503302A1] Known and novel azabicyclic derivatives of formula (I) such as quinolizidines with calcium channel antagonist activity, in which: p, and q each independently represent an integer from 3 to 5; n is 0 to 6; m is 0 to 6; A is a bond, -CH=CH-, -CC-, oxygen, sulphur or NR<1>; R<1> is hydrogen, C1-8alkyl or phenylC1-4alkyl; and Ar is aryl or heteroaryl, each of which may be optionally substituted; or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the treatment of disorders wherein a calcium channel antagonist is indicated and novel compound of formula (IA), in which: p and q each independently represent aninteger form 3 to 5; A is a bond, -CH=CH-, -CC-, oxygen, sulphur or NR<1>; R<1> is hydrogen, C1-8alkyl or phenylC1-4alkyl; na is 0 to 6 and ma is 0 to 6 such that the length of the chain (CH2)naA(CH2)ma is at least 2 atoms when A is other than S or a bond and is at least 3 atoms when A is S or a bond; and Ar is aryl or heteroaryl, each of which may be optionally substituted, with a provisos that: a) when A is a bond the group -(CH2)naA(CH2)ma is not alpha to the azabicyclic nitrogen atom; b) when A is oxygen, p and q are both 3 or both 4, na is 0 to 6 and ma is zero or 1 then Ar is not unsubstituted phenyl; and c) when A is NH, p and q do not both represent 4.
IPC 1-7
IPC 8 full level
C07D 487/04 (2006.01); A61K 31/345 (2006.01); C07D 455/02 (2006.01)
CPC (source: EP)
C07D 455/02 (2013.01)
Citation (search report)
See references of WO 9503302A1
Designated contracting state (EPC)
BE CH DE FR GB IT LI NL
DOCDB simple family (publication)
WO 9503302 A1 19950202; AU 7385894 A 19950220; EP 0710237 A1 19960508; GB 9314973 D0 19930901; JP H09500383 A 19970114; ZA 945237 B 19960118
DOCDB simple family (application)
EP 9402298 W 19940711; AU 7385894 A 19940711; EP 94923730 A 19940711; GB 9314973 A 19930720; JP 50490995 A 19940711; ZA 945237 A 19940718