Title (en)

IMMUNOREACTIVE REAGENTS EMPLOYING MONOAMINE OXIDASE

Title (de)

MONOAMIN OXIDASEN VERWENDENDE IMMUNREAKTIVE SUBSTANZEB

Title (fr)

REACTIFS IMMUNOREACTIFS UTILISANT LA MONOAMINE-OXYDASE

Publication

EP 0710244 A1 19960508 (EN)

Application

EP 94921934 A 19940607

Priority

• US 9406424 W 19940607
• US 7319893 A 19930607

Abstract (en)

[origin: WO9429333A1] In one aspect this invention describes a non radioactive targeting immunoreagent comprising the residue of a proteinaceous active site of a monoamine oxidase enzyme (MAO), a linking group, and the residue of an immunoreactive material together with a radioactive delivery agent comprising a ligand specific for said MAO receptor moiety, a linking group, and a radioactive agent. In another aspect, this invention describes a non radioactive targeting immunoreagent comprising the residue of a ligand specific for an MAO proteinaceous active site receptor moiety, a linking group, and the residue of an immunoreactive material together with a radioactive delivery agent comprising the residue of an MAO proteinaceous active site receptor moiety, a linking group, and a radioactive agent. These compositions comprise useful systems for the production of an amplification of delivery of the radioactive agent to tumor sites in the therapy and diagnostic imaging of cancer.

IPC 1-7

C07K 1/00; C07K 17/06; A61K 39/00; A61K 38/04; A61K 49/00

IPC 8 full level

A61K 35/14 (2006.01); A61K 35/50 (2006.01); A61K 39/395 (2006.01); A61K 47/48 (2006.01); A61K 51/00 (2006.01); A61K 51/10 (2006.01); C07K 1/13 (2006.01); C07K 5/02 (2006.01); C07K 5/103 (2006.01); C07K 14/705 (2006.01); C07K 16/18 (2006.01); C07K 16/30 (2006.01); C07K 17/06 (2006.01); C12N 9/06 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12Q 1/26 (2006.01); G01N 33/535 (2006.01); A61K 38/00 (2006.01); C12R 1/19 (2006.01); C12R 1/91 (2006.01)

CPC (source: EP)

A61K 47/6851 (2017.07); A61K 47/6883 (2017.07); A61K 51/1093 (2013.01); C07K 5/021 (2013.01); C07K 5/1008 (2013.01); C07K 16/30 (2013.01); C12N 9/0022 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9429333A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9429333 A1 19941222; AU 7244894 A 19950103; CA 2164518 A1 19941222; EP 0710244 A1 19960508; JP H09501147 A 19970204

DOCDB simple family (application)

US 9406424 W 19940607; AU 7244894 A 19940607; CA 2164518 A 19940607; EP 94921934 A 19940607; JP 50205595 A 19940607