Global Patent Index - EP 0713398 A1

EP 0713398 A1 19960529 - POLYPEPTIDES CODED BY EXON v5 OF THE CD44 GENE AS TARGETS FOR IMMUNOTHERAPY AND IMMUNOSCINTIGRAPHY OF TUMOURS

Title (en)

POLYPEPTIDES CODED BY EXON v5 OF THE CD44 GENE AS TARGETS FOR IMMUNOTHERAPY AND IMMUNOSCINTIGRAPHY OF TUMOURS

Title (de)

DURCH EXON v5 DES CD44-GENS KODIERTE POLYPEPTIDE ALS TARGETS FÜR IMMUNTHERAPIE UND IMMUNSZINTIGRAPHIE VON TUMOREN

Title (fr)

POLYPEPTIDES CODES PAR L'EXON v5 DU GENE CD44 UTILISES COMME CIBLES POUR L'IMMUNOTHERAPIE ET L'IMMUNOSCINTIGRAPHIE DE TUMEURS

Publication

EP 0713398 A1 19960529 (DE)

Application

EP 94924268 A 19940721

Priority

  • DE 4326573 A 19930807
  • EP 9402398 W 19940721

Abstract (en)

[origin: CA2168988A1] The present invention relates to agents for the treatment and in vivo diagnosis of tumours based on the selective bonding of antibodies to epitopes coded by variant exons of the CD44 gene. Special preference is hereby given to exon v5 of the human CD44 gene. Exon v5 is expressed in normal tissues only very slightly or not at all, whereas even at early stages of tumour progression it is expressed in large quantities. Therefore v5-coded epitopes are very suitable as targets for the immunotherapy and immunoscintigraphy of tumours.

IPC 1-7

A61K 39/395; A61K 47/48; A61K 51/10; G01N 33/577; G01N 33/574; C07K 16/42

IPC 8 full level

C07K 14/705 (2006.01); C07K 16/28 (2006.01); C12N 15/13 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01)

CPC (source: EP)

C07K 14/705 (2013.01); C07K 16/2884 (2013.01); A61K 38/00 (2013.01); A61K 39/00 (2013.01); C07K 2319/00 (2013.01)

Citation (examination)

  • THE JOURNAL OF EXPERIMENTAL MEDICINE, Bd.177, Nr.4, 1. April 1993, NEW YORK NY, VSA Seiten 897 - 904 G. KOOPMAN ET AL. 'Activated human lymphocytes and
  • aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis- associated variant of CD44.' in der Anmeldung erw{hnt
  • PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, Bd.89, Nr.24, 15.
  • Dezember 1992, WASHINGTON DC, VSA Seiten 12160 - 12164 G. SCREATON ET AL. 'Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.' in der Anmeldung erw{hnt
  • See also references of WO 9504547A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

DE 4326573 A1 19950223; AU 7459894 A 19950228; CA 2168988 A1 19950216; EP 0713398 A1 19960529; WO 9504547 A1 19950216

DOCDB simple family (application)

DE 4326573 A 19930807; AU 7459894 A 19940721; CA 2168988 A 19940721; EP 9402398 W 19940721; EP 94924268 A 19940721