EP 0714898 A1 19960605 - PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE
Title (en)
PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE
Title (de)
PYRAZOLO[1,5-a] PYRIMIDIN-DERIVATE
Title (fr)
DERIVE DE PYRAZOLO [1,5-a]PYRIMIDINE
Publication
Application
Priority
- JP 9501104 W 19950605
- JP 13863594 A 19940621
- JP 5399795 A 19950314
Abstract (en)
The invention provides a pyrazoloÄ1,5-aÜpyrimidine derivative of the following formula (1): <CHEM> wherein R<1> is hydrogen, lower alkyl which may have thienyl, lower alkoxy, lower alkylthio, oxo or hydroxyl as a substituent, cycloalkyl, thienyl, furyl, lower alkenyl, or phenyl which may have 1 to 3 substituents selected from the group consisting of lower alkyl, lower alkoxy, phenylthio and halogen; R<2> is naphthyl, cycloalkyl, furyl, thienyl, optionally halogen-substituted pyridyl, optionally halogen-substituted phenoxy, or phenyl which may have 1 to 3 substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro, halogen-substituted lower alkyl, halogen-substituted lower alkoxy, lower alkoxycarbonyl, hydroxyl, phenyl(lower)alkoxy, amino, cyano, lower alkanoyloxy, phenyl and di(lower)alkoxyphosphoryl(lower)alkyl; R<3> is hydrogen, phenyl or lower alkyl; R<4> is hydrogen, lower alkyl, lower alkoxycarbonyl, phenyl(lower)alkyl, optionally phenylthio-substituted phenyl, or halogen; R<5> is hydrogen or lower alkyl; R<6> is hydrogen, lower alkyl, phenyl(lower)alkyl, or benzoyl having 1 to 3 substituents selected from the group consisting of lower alkoxy, halogen-substituted lower alkyl and halogen; R<1> and R<5> may conjointly form lower alkylene; Q is carbonyl or sulfonyl; A is a single bond, lower alkylene or lower alkenylene; and n is 0 or 1. This derivative is useful as a potent analgesic.
IPC 1-7
IPC 8 full level
C07D 487/04 (2006.01)
CPC (source: EP KR US)
A61K 31/505 (2013.01 - KR); C07D 487/04 (2013.01 - EP KR US)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB IE IT LI LU NL PT SE
DOCDB simple family (publication)
EP 0714898 A1 19960605; EP 0714898 A4 19970402; EP 0714898 B1 20011114; AT E208776 T1 20011115; AU 2576595 A 19960115; AU 680370 B2 19970724; CA 2169719 A1 19951228; CA 2169719 C 20020416; CN 1046730 C 19991124; CN 1131948 A 19960925; DE 69523864 D1 20011220; DE 69523864 T2 20020613; DK 0714898 T3 20020318; ES 2164153 T3 20020216; KR 100315837 B1 20020228; KR 960703919 A 19960831; PT 714898 E 20020429; TW 307767 B 19970611; US 5707997 A 19980113; WO 9535298 A1 19951228
DOCDB simple family (application)
EP 95920260 A 19950605; AT 95920260 T 19950605; AU 2576595 A 19950605; CA 2169719 A 19950605; CN 95190760 A 19950605; DE 69523864 T 19950605; DK 95920260 T 19950605; ES 95920260 T 19950605; JP 9501104 W 19950605; KR 19960700854 A 19960221; PT 95920260 T 19950605; TW 84106201 A 19950616; US 60282496 A 19960221