Global Patent Index - EP 0716659 A4

EP 0716659 A4 19980902 - EPILIGRIN, AN EPITHELIAL LIGAND FOR INTEGRINS

Title (en)

EPILIGRIN, AN EPITHELIAL LIGAND FOR INTEGRINS

Title (de)

EPILIGRIN, EIN EPITHELIALER LIGAND FÜR INTEGRINE

Title (fr)

EPILIGRINE, LIGAND EPITHELIAL POUR LES INTEGRINES

Publication

EP 0716659 A4 19980902 (EN)

Application

EP 94929787 A 19940902

Priority

  • US 9410261 W 19940902
  • US 11591893 A 19930902

Abstract (en)

[origin: WO9506660A1] Nucleic acid sequences are disclosed encoding an E170 epithelial ligand and capable of hybridizing under stringent conditions to the nucleotide sequences derived from cDNA clones shown in the figure. Also disclosed are vectors containing the nucleic acid sequences, and cells transformed with the vectors. Methods are given for purifying and utilizing epiligrin, an epithelial glycoprotein complex, and its component glycoproteins, and for raising antibodies against components of this complex. Assay methods are further provided for identification of functional epiligrin in tissues.

IPC 1-7

C07H 21/02; C07H 21/04; C07K 5/00; C07K 14/00; C07K 16/00; C12N 1/21; C12N 15/70; C12P 19/34; C12Q 1/68; G01N 33/00

IPC 8 full level

C07K 14/705 (2006.01); C07K 16/18 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

C07K 14/705 (2013.01); C07K 14/70546 (2013.01); C07K 16/18 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [T] RYAN M.C. ET AL.: "Cloning of the LamA3 gene encoding the alpha-3 chain of the adhesive ligand epiligrin.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 36, 9 September 1994 (1994-09-09), pages 22779 - 22787, XP002068570
  • [PX] DATABASE EMBL 5 May 1994 (1994-05-05), ABERDAM D.: "Mus musculus nicein chain A (NicA) mRNA sequence.", XP002068571
  • [PDX] BAUDOIN C. ET AL.: "The 150 kDa sub-unit of the basement membrane component nicein is a truncated isoform of laminin chain A.", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 102, no. 4, April 1994 (1994-04-01), pages 549, XP002068693

Citation (examination)

  • ORTIZ-URDA ET AL.: "Type VII Collagen is required for Ras-driven human epidermal tumorigenesis", SCIENCE, vol. 307, 18 March 2005 (2005-03-18), pages 1773 - 1776
  • DAJEE,M. ET AL.: "NF-kB blockade and oncogenic Ras trigger invasive human epidermal neoplasia", NATURE, vol. 421, 6 February 2003 (2003-02-06), pages 639 - 642
  • BOLOTIN,D. AND FUCHS,E.: "More than skin deep", NATURE, vol. 421, 6 February 2003 (2003-02-06), pages 594 - 595
  • See also references of WO 9506660A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9506660 A1 19950309; AU 7872894 A 19950322; CA 2170777 A1 19950309; EP 0716659 A1 19960619; EP 0716659 A4 19980902; EP 1808439 A2 20070718; EP 1808439 A3 20080312

DOCDB simple family (application)

US 9410261 W 19940902; AU 7872894 A 19940902; CA 2170777 A 19940902; EP 07075129 A 19940902; EP 94929787 A 19940902