EP 0720652 A1 19960710 - RECEPTOR RECOGNITION FACTORS, PROTEIN SEQUENCES AND METHODS OF USE THEREOF
Title (en)
RECEPTOR RECOGNITION FACTORS, PROTEIN SEQUENCES AND METHODS OF USE THEREOF
Title (de)
REZEPTORERKENNUNGSFAKTOREN, DEREN PROTEIN SEQUENZEN UND VERWENDUNGEN
Title (fr)
SEQUENCE DE PROTEINES OU FACTEURS DE RECONNAISSANCE DE RECEPTEURS ET LEUR PROCEDE D'UTILISATION
Publication
Application
Priority
- US 9410849 W 19940926
- US 12658893 A 19930924
- US 12659593 A 19930924
- US 21218594 A 19940311
- US 21218494 A 19940311
Abstract (en)
[origin: WO9508629A1] Receptor recognition factors exist that recognize the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFN alpha and IFN gamma . Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission. Numerous diagnostic and therapeutic materials and utilities are also disclosed.
IPC 1-7
C12N 15/12; C07K 14/47; C07K 16/18; G01N 33/68; C12N 15/11; C12N 9/00
IPC 8 full level
C12N 15/09 (2006.01); A61K 31/70 (2006.01); A61K 38/00 (2006.01); A61K 38/21 (2006.01); A61K 48/00 (2006.01); A61P 1/16 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); C07H 21/04 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 5/10 (2006.01); C12N 9/00 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP)
A61P 1/16 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); C07K 14/4705 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9508629A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9508629 A1 19950330; AU 8072194 A 19950410; CA 2172490 A1 19950330; EP 0720652 A1 19960710; JP H09506243 A 19970624
DOCDB simple family (application)
US 9410849 W 19940926; AU 8072194 A 19940926; CA 2172490 A 19940926; EP 94931767 A 19940926; JP 50942395 A 19940926